NCT04779463Unknown不适用
Role of Ultrasound Assessment of Parasternal Intercostal Muscle Thickness During Weaning From Mechanical Ventilation
Wesameldin Abelrahman Soltan1 个研究点 分布在 1 个国家目标入组 40 人开始时间: 2020年6月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- the thickness fraction of the parasternal intercostal muscle as a predictor of successful spontaneous breathing trials
研究概览
简要总结
Assessment of the the parasternal intercostal muscles thickness by the ultrasonography as a weaning predictor of the mechanically ventilated patients
详细描述
impact of parasternal muscle thickness on the weaning process of the mechanically ventilated patients in ICU
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Any patient invasively mechanically ventilated at least 24 hours on a pressure support mode who is clinically stable and ready to undergo a spontaneous breathing trial.
- •All patients will be:
- •Afebrile.
- •Adequate cough with absence of excessive tracheobronchial secretion.
- •Fraction of inspired oxygen (FIO2) of <50%.
- •PEEP ≤8 cmH2O.
- •PaO2/FiO2 >
- •pH ≥7.35 and ≤7.
- •Respiratory rate (RR) ≤35 breaths/min.
- •Hemodynamically stable in the absence of vasopressors.
- •Stable metabolic and endocrinal status.
- •Euglycemic state.
- •Adequate mentation (no sedation or stable neurologic patient).
排除标准
- •Diaphragmatic paralysis (detected by ultrasonography).Patients&Methods. 6
- •Pregnant women.
- •Age: >= 18 years.
- •Surgical dressings over measurement point which would preclude ultrasound exam.
- •Underweight patients (Body mass index <18.5 kg/m2).
- •Morbidly obese patient (Body mass index ≥ 40 kg/m2).
- •Primary neuro-muscular diseases.
- •Central coditions with depressed central respiratory drive (encephalitis, and brainstem haemorrhage/ischaemia).
- •Repiratory conditions with reduced pulmonary compliance (interstitial lung disease, pulmonary hemorrhage, and diffuse pulmonary infiltrates) or reduced chest wall compliance (kyphoscoliosis).
- •Cardiac conditions with high risk of weaning induced pulmonary edema (congestive heart failure, cyanotic heart diease, pulmonary hypertension, and ischemic heart diease).
- •Addict patients.
- •Patients with psychiatric disease.
结局指标
主要结局
the thickness fraction of the parasternal intercostal muscle as a predictor of successful spontaneous breathing trials
时间窗: Before the start spontaneous breathing trial
The primary outcome is to assess the change of the parasternal intercostal muscles thickness at end of expiration and end of inspiration to verify the thickness fraction of the parasternal intercostal muscle as a predictor of successful spontaneous breathing trials.
次要结局
未报告次要终点
研究者
Wesameldin Abelrahman Soltan
Associate Professor
Menoufia University
研究点 (1)
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