Dyslipidaemia, Oxidative Stress And Arterial Wall Function In Non-Insulin Dependent Diabetes
Phase 2
Completed
- Conditions
- Type 2 DiabetesDyslipidaemiaMetabolic and Endocrine - DiabetesMetabolic and Endocrine - Metabolic disorders
- Registration Number
- ACTRN12611001150932
- Lead Sponsor
- Professor Gerald F Watts
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 80
Inclusion Criteria
Type 2 diabetes
Dyslipidaemia (fasting serum triglycaeride >1.8mmol/L or HDL-cholesterol <1.0mmol/L, with total cholesterol <6.5mmol/L and total cholesterol-to-HDL-cholesterol ratio >4)
Exclusion Criteria
Use of antioxidant or lipid-regulating therapy, insulin, angiotensin-converting enzyme inhibitors, calcium antagonists or aspirin
Body mass index >40kg/m2
Uncontrolled hypertension (>160/90mmHg)
Serum creatinine >150umol/
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Acetylcholine-stimulated forearm blood flow measured by strain gauge plethysmography[At baseline (week 0) and at week 12 after treatment randomisation]
- Secondary Outcome Measures
Name Time Method Hyperaemic response in forearm blood flow following venous occlusion measured by strain gauge plethysmography[At baseline (week 0) and at weeks 6 and 12 after treatment randomisation];Hyperaemic flow-mediated dilatation of the brachial artery following arterial occlusion measured by ultrasonography[At baseline (week 0) and at weeks 6 and 12 after treatment randomisation]