Effects of serotonin receptor agonism on blood glucose lowering: Proof of concept in humans

Cambridge University Hospitals NHS Foundation Trust0 个研究点目标入组 10 人开始时间: 2021年2月1日最近更新: 2021年2月16日

适应症

试验速览

暂无简介。

•1. Being able to provide written informed consent
•2. Age between 18 and 65 years
•3. Body Mass Index (BMI) =25 kg/m² and <30 kg/m² for non-Asian individuals; BMI =23 kg/m² and <25 kg/m² for Asian individuals according to the BMI classification by the World Health Organization (WHO)
•4. HbA1C <48 mmol/mol at screening
•5. Subject must not use any regular prescribed medications (this excludes simple analgesia used as needed)
•6. Subject must not use any over the counter supplements targeting metabolism
•7. Subject must not have any acute or chronic disease which in the opinion of the investigator may affect the study outcome
•8. Subject must not be a current smoker
•9. No history of substance abuse or excess alcohol consumption (>14 units/week)
•10. Women of childbearing age must have a negative pregnancy test at screening and must not be breastfeeding
•11. Women of childbearing age who are sexually active with a male partner must use highly effective contraceptive methods

•1. Use of any regular medications
•2. Use of illicit drugs
•3. Use of any over the counter supplements affecting metabolism
•4. Diagnosis of any acute/chronic disease
•5. Current smoking or excess alcohol consumption (>14 units/week)
•6. Current pregnancy or lactation
•7. Abnormal findings on physical exam or routine blood tests at screening (full blood count, urea and electrolytes, HbA1C, liver function tests)
•8. Concurrent participation in another trial with an investigational product
•9. History of anaphylaxis

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