Impact of a Motion Correction Algorithm on Image Quality and Diagnostic Utility in Patients Undergoing CT Angiography: A Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 140
- 试验地点
- 1
- 主要终点
- images with non diagnostic image quality
研究概览
简要总结
The aim of this study was to investigate the effect of a new motion correction algorithm on image quality and diagnostic utility in unselected patients undergoing coronary cardiac computed tomography, and to investigate if this motion correction algorithm can compensate for the usual use of intravenously medication (beta-blockers) before the scan.
详细描述
Aims:
To investigate the motion correction algorithm Snapshot-Freeze(SSF) compared to standard reconstruction(STD) in patients randomized to receive beta-blockers(BB) or no beta-blockers(non-BB) before coronary CT angiography (CCTA), and to investigate if SSF can replace BB.
Methods:
The study included 140 consecutively recruited patients scheduled to CCTA to rule out coronary artery disease.
The inclusion criteria were: age ≥ 18 years, Glomerular filtration rate ≥ 60 mL/min, Heart Rate between 60 and 85 bpm before the scan. The exclusion criteria were: irregular heart rhythm or history of allergic reaction to contrast agents. Patients were randomized to the BB group or the non-BB group. The trial complied with the Declaration of Helsinki and was approved by the local ethics committee. Written informed consent was obtained from all patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age ≥ 18 years,
- •glomerular filtration rate ≥ 60 mL/min,
- •heart rate between 60 and 85 bpm before the scan
排除标准
- •irregular heart rhythm
- •history of allergic reaction to contrast agents
研究组 & 干预措施
seloken
In "seloken" arm, patients performs the cardiac CT procedure regarding the national scan guidelines, ande receive 5-10 intravenous seloken, until heart rate below 60 beats pr minit is achieved.
non-seloken
Patients randomized to "non-seloken", do not receive any medication.
干预措施: non-seloken (Other)
结局指标
主要结局
images with non diagnostic image quality
时间窗: up to 1 year
number of non diagnostic images.
次要结局
- images with Excellent image quality(up to 1 year)
- motion artifacts(up to 1 year)
研究者
Hussam Mahmoud Sheta
M.D
Odense University Hospital