Comparison of efficacy of Pentoxifylline and Lycopene with intralesional Dexamethasone, Hyaluronidase in the treatment of Oral Submucous Fibrosis: A Randomized Controlled Clinical Trial

The aim of the study is to Compare the efficacy of oral Pentoxifylline and Lycopene with intralesional Dexamethasone, Hyaluronidase in the treatment of Oral Submucous Fibrosis. Out patients reporting to the Department of Oral Medicine and Radiology, Government Dental College and Hospital, Vijayawada who are diagnosed clinically with Oral Submucous Fibrosis and requires treatment will be enrolled in the study. Detailed history of health and habit will be taken and patient will be motivated to quit the habit. The intended procedure will be explained to every patient and an informed consent will be obtained thereafter.  Selected patients will be allocated into group A and B randomly. Group A: Consists of 20 OSMF patients who will be administered Intralesional injection of dexamethasone 1.5ml+ Intralesional injection of hyaluronidase 1500 IU + with 0.5ml lignocaine HCL two times per week for a period of 8 weeks. Group B: Consists of 20 OSMF patients who will be given Tablet Pentoxifylline 400 mg thrice daily combined with oral antioxidant containing Lycopene 10,000 mcg once daily for a period of 8 weeks.