Effect of treatment with an oral bisphosphonate on markers of bone formation and bone resorption in adults with alkpatonuria.
Completed
- Conditions
- Alkaptonuria.
- Registration Number
- NL-OMON28328
- Lead Sponsor
- MC Utrecht
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 6
Inclusion Criteria
1. Patients with alkaptonuria;
2. Osteopenia or osteoporose on DEXA-scan;
Exclusion Criteria
1. Short life expectancy;
2. Hepatic or renal disease;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Change in bone markers;<br /><br>2. Bone formation: Plasma alk. phosphatase;<br /><br>3. Bone resorption: Urine Type I collagen cross-linked N-telopeptide.
- Secondary Outcome Measures
Name Time Method Pain using the VAS-score.