Biomarker-guided implementation of angiotensin-II (AT-II) to reduce the occurrence of kidney damage after cardiac surgery - AIDED

Westfälische Wilhelms-Universität Münster0 个研究点目标入组 64 人开始时间: 2021年9月16日最近更新: 2021年11月29日

适应症

试验速览

暂无简介。

•1.Adult patients scheduled for cardiac surgery with cardiopulmonary bypass (CPB),
•2.18 years of age or older,
•3.cardiac index > 2.1 l/min per square meter,
•4.Written informed consent.
•Registered patients will be randomized only if
•1.?-renin (difference between post- and pre-operation) = 3.7 µU/ml 4h after CPB.
•2.postoperative hypotension requiring vasopressors
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 25
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range 39

•1.Preexisting AKI (stage 1 and higher)
•2.Patients with cardiac assist devices (ECMO, LVAD, RVAD, IABP)
•3.Pregnant women, breastfeeding women and women of childbearing potential
•4.Known (Glomerulo-) Nephritis, interstitial nephritis or vasculitis
•5.Chronic kidney disease with eGFR < 20 ml/min/1.73m2
•6.Dialysis dependent CKD
•7.Prior kidney transplant within the last 12 months
•8.Emergency surgery in the context of an acute coronary syndrome
•9.Hypersensitivity to the active substance, or to any of the excipients of the study medication
•10.Bronchospasm
•11.Liver failure
•12.Mesenteric ischemia
•13.Participation in another intervention trial in the past 3 months
•14.Persons with any kind of dependency on the investigator or employed by the institution responsible or investigator
•15.Persons held in an institution by legal or official order

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