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Clinical Trials/NCT02780466
NCT02780466
Completed
Not Applicable

Observational Study on Intubation in Septic Shock

University Hospital, Angers0 sites859 target enrollmentMay 2016
ConditionsSeptic Shock

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Septic Shock
Sponsor
University Hospital, Angers
Enrollment
859
Primary Endpoint
death
Status
Completed
Last Updated
8 years ago

Overview

Brief Summary

Septic shock is common in intensive care and its mortality remains high. While new treatments have not improved survival, optimization of known and widely used techniques has allowed reduction in mortality. Thus improving care given to patients starts with making better use of existing resuscitation techniques. Among these practices, mechanical ventilation is widespread in the management of patients with septic shock. In large studies published in recent years in Europe and North America, 40 to 85% of patients receive invasive mechanical ventilation. It therefore appears that a significant proportion of patients are never intubated during treatment and management of their septic shock. There is no specific recommendation from critical care societies concerning mechanical ventilation in the treatment of septic shock. Apart from indisputable situations such as impaired consciousness or acute respiratoire distress, the decision whether to ventilate mechanically or not is left to the discretion of the physician.

The aim of this study is to analyze intubation practice in septic shock patients and its impact on 28-day survival.

This multicentric and observational study will be conducted in 30 French ICUs.

Registry
clinicaltrials.gov
Start Date
May 2016
End Date
April 2018
Last Updated
8 years ago
Study Type
Observational
Sex
All

Investigators

Sponsor
University Hospital, Angers
Responsible Party
Principal Investigator
Principal Investigator

DENISE JOLIVOT

Coordinator for medical research

University Hospital, Angers

Eligibility Criteria

Inclusion Criteria

  • older than 18 years old
  • Admitted in the ICU for septic shock
  • Introduction of vasopressors ( norepinephrine or adrenaline ) in the ICU or within 24 hours of ICU admission
  • Suspected or proven infection

Exclusion Criteria

  • Intubation before the introduction of vasopressors
  • Decision of withdrawing or withholding care at admission
  • Pregnant woman
  • Patient not affiliated to the social security insurance
  • Refusal of participation in the study

Outcomes

Primary Outcomes

death

Time Frame: 28 days after ICU admission

Secondary Outcomes

  • duration of organ support(28 days)
  • impact of intubation delay on outcome(28 days)

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