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临床试验/NCT02780466
NCT02780466已完成不适用

Observational Study on Intubation in Septic Shock

University Hospital, Angers0 个研究点目标入组 859 人开始时间: 2016年5月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
859
主要终点
death

研究概览

简要总结

Septic shock is common in intensive care and its mortality remains high. While new treatments have not improved survival, optimization of known and widely used techniques has allowed reduction in mortality. Thus improving care given to patients starts with making better use of existing resuscitation techniques. Among these practices, mechanical ventilation is widespread in the management of patients with septic shock. In large studies published in recent years in Europe and North America, 40 to 85% of patients receive invasive mechanical ventilation. It therefore appears that a significant proportion of patients are never intubated during treatment and management of their septic shock. There is no specific recommendation from critical care societies concerning mechanical ventilation in the treatment of septic shock. Apart from indisputable situations such as impaired consciousness or acute respiratoire distress, the decision whether to ventilate mechanically or not is left to the discretion of the physician.

The aim of this study is to analyze intubation practice in septic shock patients and its impact on 28-day survival.

This multicentric and observational study will be conducted in 30 French ICUs.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • older than 18 years old
  • Admitted in the ICU for septic shock
  • Introduction of vasopressors ( norepinephrine or adrenaline ) in the ICU or within 24 hours of ICU admission
  • Suspected or proven infection

排除标准

  • Intubation before the introduction of vasopressors
  • Decision of withdrawing or withholding care at admission
  • Pregnant woman
  • Patient not affiliated to the social security insurance
  • Refusal of participation in the study

结局指标

主要结局

death

时间窗: 28 days after ICU admission

次要结局

  • duration of organ support(28 days)
  • impact of intubation delay on outcome(28 days)

研究者

发起方
University Hospital, Angers
申办方类型
Other Gov
责任方
Principal Investigator
主要研究者

DENISE JOLIVOT

Coordinator for medical research

University Hospital, Angers

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