Observational Study on Intubation in Septic Shock
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 859
- 主要终点
- death
研究概览
简要总结
Septic shock is common in intensive care and its mortality remains high. While new treatments have not improved survival, optimization of known and widely used techniques has allowed reduction in mortality. Thus improving care given to patients starts with making better use of existing resuscitation techniques. Among these practices, mechanical ventilation is widespread in the management of patients with septic shock. In large studies published in recent years in Europe and North America, 40 to 85% of patients receive invasive mechanical ventilation. It therefore appears that a significant proportion of patients are never intubated during treatment and management of their septic shock. There is no specific recommendation from critical care societies concerning mechanical ventilation in the treatment of septic shock. Apart from indisputable situations such as impaired consciousness or acute respiratoire distress, the decision whether to ventilate mechanically or not is left to the discretion of the physician.
The aim of this study is to analyze intubation practice in septic shock patients and its impact on 28-day survival.
This multicentric and observational study will be conducted in 30 French ICUs.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •older than 18 years old
- •Admitted in the ICU for septic shock
- •Introduction of vasopressors ( norepinephrine or adrenaline ) in the ICU or within 24 hours of ICU admission
- •Suspected or proven infection
排除标准
- •Intubation before the introduction of vasopressors
- •Decision of withdrawing or withholding care at admission
- •Pregnant woman
- •Patient not affiliated to the social security insurance
- •Refusal of participation in the study
结局指标
主要结局
death
时间窗: 28 days after ICU admission
次要结局
- duration of organ support(28 days)
- impact of intubation delay on outcome(28 days)
研究者
DENISE JOLIVOT
Coordinator for medical research
University Hospital, Angers
