PRF for Accelerating Palatal Healing

Not Applicable

Completed

• Conditions: Gingival Recession
• Interventions: Other: Wet gauze; Other: Platelet Rich Fibrin; Other: Butyl cyanoacrylate

• Registration Number: NCT02712242
• Lead Sponsor: Cukurova University

Brief Summary

Backgroung: Various agents are used to reduce post-operative complications associated with palatal donor site surgery for free gingival graft (FGG) harvesting. This study was conducted to evaluate the effects of platelet-rich fibrin (PRF) on palatal wound healing.

Detailed Description

125 patients with isolated recessions were treated. The connective tissue graft was obtained by the de-epithelialization of a free gingival graft in both groups. Three different hemostatic treatments were randomized; PRF with cyanoacrilate adhesive (PRF group, n:42), cyanoacrilate adhesive alone (BC group, n:42) and sterile wet gauze compression (WG group, n:41). Immediate and delayed bleeding, pain, epithelialization, feeding habits and sensation scores were recorded for different time points.

Study Timeline

• Study Start: 2013-11
• Primary Completion: 2015-05
• Study Completion: 2015-09
• Status Verified: 2016-03
• Study First Submitted: 2016-03-09
• Study First Submitted QC: 2016-03-14
• Last Update Submitted: 2016-03-14
• Study First Posted: 2016-03-18
• Last Update Posted: 2016-03-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 125

Inclusion Criteria

• no contraindications for periodontal surgery;
• full-mouth plaque score of <10%
• full-mouth bleeding score of <15%.

Exclusion Criteria

• previously undergone surgery for a graft harvested from the palate
• presence of systemic disease or taking medication known to interfere with periodontal health
• smokers
• possible coagulation disorders

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Wet Gauze	Wet gauze	Wet Gauze was placed for 1 minute on the palatal wound after harvesting the tissue graft
Platelet Rich Fibrin	Platelet Rich Fibrin	PRF was laid directly on the palatal wound immediately after harvesting the tissue graft and stabilized
Butyl cyanoacrylate	Butyl cyanoacrylate	Butyl cyanoacrylate was directly applied on the palatal wound after harvesting the tissue graft

Primary Outcome Measures

Name	Time	Method
Epithelialization	One month	Assessed according to the toluedine blue coloring

Secondary Outcome Measures

Name	Time	Method
Delayed bleeding	1 week	Bleeding assesment for post-operative one week
feeding habits	One month	visual analogue scale scores
Sensibility disorders	One month	visual analogue scale scores
Pain	3 months	Visual Analague Scale scores
Immediate Bleeding	1 hour	Bleeding assesment for post-operative one hour