The Effects of Platelet-Rich Fibrin on Palatal Wound Healing After Free Gingival Graft Harvesting: A Comparative Randomized Controlled Clinical Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 125
- 主要终点
- Epithelialization
研究概览
简要总结
Backgroung: Various agents are used to reduce post-operative complications associated with palatal donor site surgery for free gingival graft (FGG) harvesting. This study was conducted to evaluate the effects of platelet-rich fibrin (PRF) on palatal wound healing.
详细描述
125 patients with isolated recessions were treated. The connective tissue graft was obtained by the de-epithelialization of a free gingival graft in both groups. Three different hemostatic treatments were randomized; PRF with cyanoacrilate adhesive (PRF group, n:42), cyanoacrilate adhesive alone (BC group, n:42) and sterile wet gauze compression (WG group, n:41). Immediate and delayed bleeding, pain, epithelialization, feeding habits and sensation scores were recorded for different time points.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 21 Years 至 48 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •no contraindications for periodontal surgery;
- •full-mouth plaque score of <10%
- •full-mouth bleeding score of <15%.
排除标准
- •previously undergone surgery for a graft harvested from the palate
- •presence of systemic disease or taking medication known to interfere with periodontal health
- •possible coagulation disorders
研究组 & 干预措施
Butyl cyanoacrylate
Butyl cyanoacrylate was directly applied on the palatal wound after harvesting the tissue graft
干预措施: Butyl cyanoacrylate (Other)
Wet Gauze
Wet Gauze was placed for 1 minute on the palatal wound after harvesting the tissue graft
干预措施: Wet gauze (Other)
Platelet Rich Fibrin
PRF was laid directly on the palatal wound immediately after harvesting the tissue graft and stabilized
干预措施: Platelet Rich Fibrin (Other)
结局指标
主要结局
Epithelialization
时间窗: One month
Assessed according to the toluedine blue coloring
次要结局
- Delayed bleeding(1 week)
- feeding habits(One month)
- Sensibility disorders(One month)
- Pain(3 months)
- Immediate Bleeding(1 hour)
研究者
Onur Ozcelik
Professor
Cukurova University