TO STUDY THE ROLE OF NEUTROPHIL TO LYMPHOCYTE RATIO AS A MEASURE OF SUGAR CONTROL AS COMPARED TO STANDARD TEST OF GLYHB.

Not yet recruiting

Conditions: PATIENTS WITH TYPE 2 DIABETES

Registration Number: CTRI/2017/03/008089

Lead Sponsor: KASTURBA HOSPITAL

Brief Summary: Aim-Evaluation of role of neutrophil to lymphocyte ratio as a marker of inflammatory state and blood sugar control in type 2 diabetes.

Objectives-1)To study the association between neutrophil to lymphocyte ratio and GlyHb in Type 2 Diabetes mellitus.2)To study the association of HsCRP and GlyHb in Type 2 Diabetes mellitus.3)To study the association of neutrophil to lymphocyte ratio with HsCRP and GlyHb in Type 2 Diabetes mellitus.

sample size-100.

Description-Patients with Type 2 Diabetes meeting the inclusion/exclusion criteria will be included in the study after taking informed consent.Patients will be asked routine history and physical examination will be done.Tests like FBS,PPBS,GlyHb,absolute neutrophil count,absolute lymphocyte count will be done as standard of care.In this study we will draw an additonal blood sample/residual blood sample and perform HsCRP on it.

Ethical consideration-the cost estimated with HsCRP is the only test that is not done as a part of standard of care,during the participation of the patient in the study,the cost will be born by the investigator.

Budget and funding source-30,000/- ,KMC Manipal.

Review of literature-patients with T2DM are in a state of low degree of chronic inflammation that induces hypersecretion of inflammatory factors,such as CRP,IL-6,TNF-alfa and MCP-1,which resultsin a constantly elevated neutrophilic granulocyte count.One mechanism by which increased levels of neutrophil could mediate insulin resistance may be through augmented inflammation.The increase in NLR appears to underlie the elevated levels of proinflammation,as evident from the persistent neutrophil activation and enhanced release of neutrophil proteases with T2DM.Lymphocytes are reduced as a result of hyperglycemia in T2DM.Also there is an insufficient proliferation of lymphocytes due to low experession of Il-2 receptor.Neutrophil to lymphocyte ratio is an essential marker of systemic inflammation.CRP produced by liver is acute phase response protein increased during inflammation.Many studies done showed-the HsCRP levels were elevated in diabetic subjects,compared with non diabetic subjects.So,studies have suggested that the ratio can be used as marker of inflammation in T2DM.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 100

Inclusion Criteria

Patients with Type 2 Diabetes admitted in kasturba hospital who have given informed consent.

Exclusion Criteria

Acute/chronic inflammatory states,acute/chronic kidney disease,chronic liver disease,leukemia,lymphoma,malignancies.

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To evaluate role of neutrophil to lymphocyte ratio as a marker of inflammatory state and blood sugar control in type 2 diabetes.	NOVEMBER 2018

Secondary Outcome Measures

Name	Time	Method
To study the association of HsCRP and GlyHb in type 2 diabetes	NOVEMBER 2018

Trial Locations

Locations (1): KASTURBA HOSPITAL
🇮🇳
Udupi, KARNATAKA, India
KASTURBA HOSPITAL
🇮🇳Udupi, KARNATAKA, India
DR POORNIMA S TADKAL
Principal investigator
9742709600
tadkalpoornima29@gmail.com