Evaluation of the effect of Pistacia atlantica oleoresin on Irritable bowel syndrome

Phase 3

Conditions: Irritable bowel syndrome.
Irritable bowel syndrome without diarrhea
K58.9

Registration Number: IRCT20211214053405N1

Lead Sponsor: Babol University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: All

Target Recruitment: 70

Inclusion Criteria

The patient has not been treated with Pistacia atlantica oleoresin for the past month
Patients with IBS whose type of disease has been confirmed by a complete medical examination.
The patient signs a written consent
Age over 18 years

Exclusion Criteria

Pregnant or lactating women
Patients with malignancies or other chronic gastrointestinal diseases such as inflammatory bowel disease and celiac disease
History of major gastrointestinal surgery (including Billroth surgery, ostomy, and any resection in any part of the gastrointestinal tract).
Inability to swallow capsules
People taking psychotherapy drugs
Patients at a serious health risk, including severe heart, liver or kidney disease
Patients with severe plant allergies
Regular use of drugs that change the movement of the gastrointestinal tract such as metoclopramide, cisapride, drugs, diphenoxylate, etc.
Regular use of laxatives
Follow the diet plans with daily and regular intake of prebiotic/probiotic compounds
Taking antibiotics
The patient has been treated with Pistacia atlantica for the past month
Cigarette smoking, alcohol usage
NSAID usage

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in the severity of irritable bowel syndrome based on the total score of the IBS-SSS scale. Timepoint: The beginning of the study and the sixth week of the intervention and one month after the intervention. Method of measurement: Irritable Bowel Syndrome Severity Questionnaire (IBS-SSS).

Secondary Outcome Measures

Name	Time	Method
Quality of life based on change in total score of IBS-QOL quality of life questionnaire, change in symptoms of IBS-SSS Irritable Bowel Syndrome Scale. Timepoint: Initially study and the sixth week of intervention and one month after intervention. Method of measurement: Quality of Life Questionnaire for Patients with Irritable Bowel Syndrome (IBS-QOL).;The severity of symptoms subsets of the IBS-SSS Irritable Bowel Syndrome questionnaire. Timepoint: Initially study and the sixth week of intervention and one month after intervention. Method of measurement: IBS-SSS questionnaire.