Role of central venous-arterial pCO2 difference(pCO2 gap) in prediction of clinical outcome and prognosis of patients in septic shock.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 101
- 试验地点
- 1
- 主要终点
- 28 day mortality rate
研究概览
简要总结
A prospective observational study will be conducted in a 17 bedded ICU setup of a Multispecialty, University affiliated hospital. A written and informed consent will be taken from the patients/their next of kin(NOK), meeting the inclusion criteria of the study. ABG and VBG samples will be taken for patients diagnosed to be in septic shock, through central venous catheter and arterial catheter respectively. The samples will be taken at T= 0 Hrs and T= 6 Hrs, where T0 is the time at which the patient was started on vasopressor support.
PCO2 gap found (the worse value among T0 and T6) will be considered and correlated with 28 day mortality rates of the patients.
Similarly PCO2 values will also be correlated with : Serum Lactate levels, SOFA score and Length of stay in ICU
Positive correlation will be considered if there are higher 28 day mortality rates with ð›¥PCO2 > 6mmHg.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 90.00 Year(s)（—）
- 性别
- All
入选标准
- •Adult patients admitted as a case of Septic Shock with Vasopressor requirement to maintain Mean Arterial Pressure greater than 65mmHg, Serum Lactate level above 2mmol/L and without any hypovolemia.
排除标准
- •Pregnancy, age below 18yrs, patients with end stage neoplasms, and patients suffering from lung diseases.
结局指标
主要结局
28 day mortality rate
时间窗: 28 days
次要结局
- Length of stay in ICU, SOFA score, and Serum Lactate levels(28 days)
研究者
Navneet Singh
Command Hospital Air Force Bangalore