COVID-19 and Childhood Cancer

Active, not recruiting

• Conditions: Childhood Cancer; COVID-19; Childhood Leukemia, Acute Lymphoblastic

• Registration Number: NCT06482281
• Lead Sponsor: Karolinska Institutet

Brief Summary

The investigators will first examine the impact of the COVID-19 pandemic on childhood cancer patients in Sweden and Denmark, both regarding susceptibility to severe COVID-19 among long-term childhood cancer survivors, and, for those diagnosed with childhood cancer during the pandemic, whether the path through primary care to cancer diagnosis as well as short-term survival has changed. Second, the investigators will study childhood cancer incidence before, during and after the pandemic with the particular aim to test the hypothesis regarding an infectious disease etiology for acute lymphoblastic leukemia.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-01-01
• Study First Submitted: 2024-06-28
• Study First Submitted QC: 2024-06-28
• Status Verified: 2024-07
• Study First Posted: 2024-07-01
• Last Update Submitted: 2024-07-02
• Last Update Posted: 2024-07-03
• Primary Completion: 2025-12-31
• Study Completion: 2025-12-31

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 100000

Inclusion Criteria

Not provided

Exclusion Criteria

• No exclusion criteria

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Childhood cancer survival	After three and twelve months after the cancer diagnosis and three years after cancer diagnosis	Overall survival after a childhood cancer diagnosis
Severe COVID-19	Up to 3 years	Defined as: * death with COVID-19 listed as a cause of death; * hospitalization, or admission to intensive care unit, because of COVID-19 (main diagnosis) or respiratory problems (main diagnosis) AND COVID-19 as secondary diagnosis
Number of contacts before childhood cancer diagnosis	One year before cancer diagnosis	Number of healthcare contacts (including primary care) the year before the cancer diagnosis
Childhood cancer incidence	From 2015	Age standardized incidence rates for childhood cancer and cancer subtypes (particularly acute lymphoblastic leukemia) in Sweden and Denmark during and after the pandemic and compare it to the 5 years preceding the pandemic

Trial Locations

Locations (1)

Karolinska Institutet; 🇸🇪 Stockholm, Sweden