COVID-19 and Childhood Cancer - Diagnostic Delay, Survival, and COVID-19 Susceptibility
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- COVID-19
- Sponsor
- Karolinska Institutet
- Enrollment
- 100000
- Locations
- 1
- Primary Endpoint
- Childhood cancer survival
- Status
- Active, not recruiting
- Last Updated
- last year
Overview
Brief Summary
The investigators will first examine the impact of the COVID-19 pandemic on childhood cancer patients in Sweden and Denmark, both regarding susceptibility to severe COVID-19 among long-term childhood cancer survivors, and, for those diagnosed with childhood cancer during the pandemic, whether the path through primary care to cancer diagnosis as well as short-term survival has changed. Second, the investigators will study childhood cancer incidence before, during and after the pandemic with the particular aim to test the hypothesis regarding an infectious disease etiology for acute lymphoblastic leukemia.
Investigators
Giorgio Tettamanti
Senior research specialist, Docent
Karolinska Institutet
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- •No exclusion criteria
Outcomes
Primary Outcomes
Childhood cancer survival
Time Frame: After three and twelve months after the cancer diagnosis and three years after cancer diagnosis
Overall survival after a childhood cancer diagnosis
Severe COVID-19
Time Frame: Up to 3 years
Defined as: * death with COVID-19 listed as a cause of death * hospitalization, or admission to intensive care unit, because of COVID-19 (main diagnosis) or respiratory problems (main diagnosis) AND COVID-19 as secondary diagnosis
Number of contacts before childhood cancer diagnosis
Time Frame: One year before cancer diagnosis
Number of healthcare contacts (including primary care) the year before the cancer diagnosis
Childhood cancer incidence
Time Frame: From 2015
Age standardized incidence rates for childhood cancer and cancer subtypes (particularly acute lymphoblastic leukemia) in Sweden and Denmark during and after the pandemic and compare it to the 5 years preceding the pandemic