Impact of Zinc to Copper Ratio and Lipocalin 2 in Obese Patients Undergoing Sleeve Gastrectomy.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 107
- 主要终点
- Evaluation of zinc to copper ratio as biomarker of micro-nutrient deficiency
研究概览
简要总结
The aim of the study primarily was to investigate the value of zinc to copper ratio as possible biomarker of trace elements imbalance in morbidly obese subjects undergoing LSG.
Secondly to correlate zinc to copper ratio with lipocalin 2 (Lcn2) with respect to Anthropometric measurements and other metabolic biomarkers.
Prospective study will be carried out on 120 morbidly obese adult subjects with a body mass index (BMI) score above 40 along with presence of obesity-related comorbidity. Investigations will be measured preoperative and 9 months postoperative after performing Laparoscopic sleeve gastrectomy; for Body mass index (BMI) and waist circumference. As well as for complete blood count and biochemical biomarkers as fasting blood glucose, lipid profile, serum iron and ferritin. Serum Ceruloplasmin, Zn and Cu levels, followed by calculation of zinc to copper ratio. CRP, serum insulin, serum leptin and lipocalin-2 (Lcn2) will be determined.
详细描述
CONSORT 2010 Flow Diagram
Materials and methods:
Recruitment Morbidly obese subjects attending clinic at Surgery department for laparoscopic sleeve gastrectomy Alexandria University Hospitals.
Pre-assignment Details adult morbidly obese subjects were included age above 20 years, BMI above 40 Suffering from comorbidities as hypertension, DM, dyslipidemia. Assigned participants were clinically evaluated for comorbidities as hypertension, DM, dyslipidemia.
As well as signs of nutritional deficiency as anemia, brittle nails.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •micronutrient deficiency in morbid obese subjects Adults.
- •BMI above 40
- •presence of comorbidities as hypertenion, DM, dislipidemia
排除标准
- •all causes which might cause micronutrient deficiency as presence of gastroesophageal reflux
- •all causes which may cause increase obesity "BMI" as hormonal disturbance ; hypothyroidism or cushing, females receiving contraceptive pills
结局指标
主要结局
Evaluation of zinc to copper ratio as biomarker of micro-nutrient deficiency
时间窗: nine months
detect if there are micronutrient deficiency in morbid obesity in form of zinc to copper ratio and re-evaluate it after loss of weight
次要结局
- correlate zinc to copper ratio to lipocalin 2 and other metabolic biomarkers(nine months)
研究者
hala mourad demerdash
Consultant Clinical Pathology
Alexandria University