Sepsis at Södersjukhuset-Adherence to Treatment Guidelines

• Conditions: Sepsis

• Registration Number: NCT04055727
• Lead Sponsor: Karolinska Institutet

Brief Summary

A retrospective single-center study with patients with suspected sepsis admitted to the Emergency Department at Södersjukhuset during a period of two years. The aim is to describe the association between adherence to treatment guidelines, gender, incidence and mortality for patients with sepsis.

Detailed Description

In this single-center study, patients with suspected sepsis admitted to the Emergency Department at Södersjukhuset during a period of two years will be included. About 11,000 patients will be included. Patient data including described sepsis symptoms will be drawn from the electronic medical record, TakeCare and Clinisoft. Logistic regression analysis will adjust for age, gender, comorbidity according to Charlson score, vital signs, with preliminary focus of infection (pneumonia, urinary tract infection, abdominal, other, unknown). The Surviving Sepsis guidelines for the time period are: 3-hour bundle including lactate measurement, obtaining blood culture, fluid treatment if hypotensive and administration of broad-spectrum antibiotics. The 6-hour bundles with administration of vasopressors if needed, remeasure lactate if elevated, with persistent hypotension re-asses volume status and tissue perfusion. Time zero is defined as the admission time to the emergency department. The aim is to describe the association between adherence to treatment guidelines, gender, incidence and mortality for patients with sepsis.

Study Timeline

• Study Start: 2019-03-07
• Study First Submitted: 2019-08-12
• Study First Submitted QC: 2019-08-13
• Study First Posted: 2019-08-14
• Status Verified: 2021-11
• Last Update Submitted: 2021-11-11
• Last Update Posted: 2021-11-12
• Primary Completion: 2022-09-01
• Study Completion: 2022-09-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 11000

Inclusion Criteria

Not provided

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Exclusion Criteria

Not provided

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Gender differences in 90-day mortality	90 days	Gender differences in percentage of patients who died before day 90

Secondary Outcome Measures

Name	Time	Method
Association between adherence to treatment guidelines and mortality	90 days	Association between number of completed sepsis bundles and mortality
Incidence of sepsis	90 days	Number of patients admitted to the Emergency Department at Södersjukhuset during the study period comparing to the hospitals catchment area

Trial Locations

Locations (1)

Södersjukhuset; 🇸🇪 Stockholm, Sweden