Melatonin Decreases Eye Pressure in Normotensive Patients

Completed

• Conditions: Depressive Disorder
• Interventions: Drug: Agomelatine 25 MG Oral Tablet

• Registration Number: NCT03193112
• Lead Sponsor: Kahramanmaras Sutcu Imam University

Brief Summary

Agomelatine is a melatonin drug used to treat depressive disorder. Agomelatine may also some effects on ocular pressures. In this study, we aimed to demonstrate that melatonin decreases intraocular pressures when given depressive patients.

Detailed Description

Melatonin has been shown to be effective to decrease intraocular pressure in experimental animal researches. Agomelatine is a melatonin derivative drug approved for the treatment of depression, which is also available in our country. Depending on animal experiments, it can be assumed that agomelatine can decrease intraocular pressure. Demonstrating that agomelatine is effective to reduce eye pressure may give a concurrent treatment of depressive patients with glaucoma. With this it may be possible to treat both diseases at the same time with single drug. In this study, the researchers intended to investigate the changes in ocular tension in normotensive depressive patients treated with agomelatine.

Study Timeline

• Study Start: 2017-06-16
• Study First Submitted: 2017-06-16
• Study First Submitted QC: 2017-06-19
• Study First Posted: 2017-06-20
• Primary Completion: 2017-10-15
• Study Completion: 2018-06-15
• Status Verified: 2018-08
• Last Update Submitted: 2018-08-10
• Last Update Posted: 2018-08-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Depressive patients suitable for Agomelatine therapy for the treatment of their primary disease.

Exclusion Criteria

• Any past history of ocular surgery, ocular trauma or existing ocular diseases

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Study group	Agomelatine 25 MG Oral Tablet	The investigators analyze the intraocular pressure changes on patients who have been using Agomelatine for their primary depressive disorder. For the treatment of depression, patients will have been started routinely Agomelatine tablet of 25 mg orally. The investigators measure the eye pressure for one months in those patients receiving standard depression treatment.

Primary Outcome Measures

Name	Time	Method
Intraocular pressure	One month	mmHg

Trial Locations

Locations (1)

Kahramanmaras Sutcuimam University Ophthalmology Department; 🇹🇷 Kahramanmaraş, Turkey