Melatonin Decreases Eye Pressure in Depressive Patients With Normal Intraocular Pressure
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Intraocular pressure
研究概览
简要总结
Agomelatine is a melatonin drug used to treat depressive disorder. Agomelatine may also some effects on ocular pressures. In this study, we aimed to demonstrate that melatonin decreases intraocular pressures when given depressive patients.
详细描述
Melatonin has been shown to be effective to decrease intraocular pressure in experimental animal researches. Agomelatine is a melatonin derivative drug approved for the treatment of depression, which is also available in our country. Depending on animal experiments, it can be assumed that agomelatine can decrease intraocular pressure. Demonstrating that agomelatine is effective to reduce eye pressure may give a concurrent treatment of depressive patients with glaucoma. With this it may be possible to treat both diseases at the same time with single drug. In this study, the researchers intended to investigate the changes in ocular tension in normotensive depressive patients treated with agomelatine.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 66 Years(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Depressive patients suitable for Agomelatine therapy for the treatment of their primary disease.
排除标准
- •Any past history of ocular surgery, ocular trauma or existing ocular diseases
研究组 & 干预措施
Study group
The investigators analyze the intraocular pressure changes on patients who have been using Agomelatine for their primary depressive disorder. For the treatment of depression, patients will have been started routinely Agomelatine tablet of 25 mg orally. The investigators measure the eye pressure for one months in those patients receiving standard depression treatment.
干预措施: Agomelatine 25 MG Oral Tablet (Drug)
结局指标
主要结局
Intraocular pressure
时间窗: One month
mmHg
次要结局
未报告次要终点
研究者
Gokhan Ozdemir
Principal investigator, Clinical Professor
Kahramanmaras Sutcu Imam University
