Prewarming of surgical patients to prevent hypotension on induction of anaesthesia

Not Applicable

Completed

• Conditions: Hypotension on anaesthetic induction; Anaesthesiology - Anaesthetics; Surgery - Other surgery

• Registration Number: ACTRN12615000431527
• Lead Sponsor: Jai Darvall

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-05-06
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 32

Inclusion Criteria

1. Neurosurgical patients aged 18 years and over
2. Craniotomy for any indication
3. American Society of Anesthesiologists’ (ASA) physical status 1-3

Exclusion Criteria

1. Inadequate English comprehension due to a language barrier, cognitive deficit or intellectual disability
2. Significant cardiorespiratory impairment (i.e. ASA 4-5 patients)
3. Severe hypertension (systolic BP > 180 mmHg, diastolic BP > 110 mmHg in the operating suite admission bay)
4. Antihypertensive therapy with ACE inhibitor/angiotensin II receptor antagonist if administered on the day of surgery
5. Secondary hypertension (e.g. renal artery stenosis, phaeochromocytoma, Cushing's syndrome)
6. Temperature > 37.5 degrees Celcius at baseline
7. Thyroid dysfunction
8. Otitis media/externa (preventing accurate tympanic membrane temperature measurement)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Absolute difference in immediate pre- and nadir post-induction mean arterial pressure (MAP) using an arterial line[Immediately prior to laryngoscopy]

Secondary Outcome Measures

Name	Time	Method
Vasopressor dose and type used, composite secondary outcome. Contemporaneously recorded[Immediately prior to laryngoscopy];Incidence of hypotension defined as a decrease in mean blood pressure > 20% from immediate pre-induction value. [Immediately prior to laryngscopy]