The Effect of Androgen and Growth Hormone on Height and Learning in Girls With Turner Syndrome
- Registration Number
- NCT00029159
- Lead Sponsor
- Thomas Jefferson University
- Brief Summary
The purposes of this study are to learn whether treatment with an androgen type hormone will improve the visual-spatial problems associated with Turner syndrome, and to evaluate the effect growth hormone, with and without androgen, has on growth.
- Detailed Description
Turner syndrome is associated with short stature, multiple physical stigmata, absent pubertal development, and increased learning problems. This study is designed to (1) examine the effects of sex steroids (androgen and estrogen) on multiple variables including growth rate, GH binding protein, IGF-I, IGFBP3, and cognitive function in the setting of supplemental growth hormone administration and (2) to investigate any synergistic or additive effects of the androgen and estrogen combination versus each alone, on the above variables.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 200
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 1 estrogen - 1 androgen - 2 estrogen - 2 placebo -
- Primary Outcome Measures
Name Time Method Cognitive function in girls with Turner Syndrome 4 years
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (2)
Thomas Jefferson University Hospital, 1025 Walnut Street, Suite 726
🇺🇸Philadelphia, Pennsylvania, United States
National Institutes of Health
🇺🇸Bethesda, Maryland, United States