ISRCTN19419571已完成不适用
Aldosterone blockade in children with chronic allograft nephropathy: A prospective randomized controlled trial with patient blinding
Sectorial Fund for Health Research (Fondo Sectorial de Investigación en Salud) (Mexico)0 个研究点目标入组 62 人开始时间: 2010年6月18日最近更新:
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 62
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Patients aged 6 to 17 years within at least six months of receiving renal transplant
- •2. Patients with stable graft function defined as serum creatinine variation in the previous three months lower than 0.2 mg/dL
- •3. Chronic allograft nephropathy diagnosed by renal biopsy and Banff criteria
- •4. No evidence of acute rejection in the previous three months before enrolment
- •5. Glomerular filtration rate > 40 mL/min ( Schwartz formula).
- •6. Serum potassium = 5 mEq/L
- •7. Informed consent/assent properly signed
排除标准
- •1. Acute graft rejection in the three months prior to enrolment
- •2. Serum creatinine variation in the previous three months > 0.2 mg/dL
- •3. Plasma Serum potassium > 5 mEq/L
- •4. Arterial hipotension
- •5. Patients receiving clarytromicin, calcium antagonists, itraconazol, fluconazol, erythromycin
- •6. Use of eplerenone 4 prior to enrolment
研究者
相似试验
进行中（未招募）
不适用
Aldosterone receptor blockade in patients with chronic kidney disease.Influence on arterial stiffness and kidney function. - ALBLOCK-2Chronic kidney disease, stages 3 and 4.MedDRA version: 9.1Level: LLTClassification code 10064848Term: Chronic kidney diseaseEUCTR2009-012445-35-DKHerlev Hospital80
进行中（未招募）
不适用
Antagonistas aldosterónicos en el tratamiento de pacientes con ventrículo derecho sistémico: ensayo clínico aleatorizado. - EVEDES STUDY.Transposición de grandes vasos tratada mediante la técnica de redirección auricular (técnicas de Senning o Mustard).MedDRA version: 9.1Level: LLTClassification code 10010143Term: Complete transposition of great vesselsMedDRA version: 9.1Level: LLTClassification code 10044443Term: Transposition of the great vesselsEUCTR2007-002605-53-ESFundació Institut de Recerca de l'Hospital de la Santa Creu i de Sant Pau
进行中（未招募）
1 期
ALdosterone antagonist Chronic HEModialysis Interventional Survival Trialend-stage renal failure (ESRF)cardiovascular complicationMedDRA version: 20.0Level: PTClassification code 10007649Term: Cardiovascular disorderSystem Organ Class: 10007541 - Cardiac disordersMedDRA version: 20.0Level: LLTClassification code 10050441Term: Chronic renal insufficiencySystem Organ Class: 100000004857EUCTR2012-002856-18-BECHRU de Brest825
进行中（未招募）
不适用
ALdosterone antagonist Chronic HEModialysis Interventional Survival TrialEUCTR2012-002856-18-FRCHRU de Brest
进行中（未招募）
不适用
Establishing the benefits of a tablet commonly used to treat raised blood pressure in people with Chronic Kidney Disease stage 3b.We plan a large pragmatic trial to test the potential for spironolactone to to reduce overall cardiovascular events and death, to delay the decline in renal function, and to improve surrogate markers for vascular disease in people with stage 3b (eGFR 30-44 ml/min/1.73m2)Chronic Kidney Disease.MedDRA version: 15.1Level: LLTClassification code 10064848Term: Chronic kidney diseaseSystem Organ Class: 100000004857MedDRA version: 15.1Level: PTClassification code 10018355Term: Glomerular filtration rateSystem Organ Class: 10022891 - InvestigationsMedDRA version: 15.1Level: LLTClassification code 10007648Term: Cardiovascular disease, unspecifiedSystem Organ Class: 100000004849EUCTR2012-002672-13-GBniversity of Oxford, Clinical Trials and Research Governance Office2,616