Evaluation of the patients with severe traumatic brain injury receiving the curcumin-piperine supplement
Phase 3
Recruiting
- Conditions
- Severe traumatic brain injury.Diffuse traumatic brain injuryS06.2
- Registration Number
- IRCT20201220049774N5
- Lead Sponsor
- Mashhad University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 44
Inclusion Criteria
Age between 18 and 70 years
Less than 12 hours have passed since the brain trauma.
The patient has been diagnosed with severe non-penetrating traumatic brain injury.
The patient's GCS at the time of visit should be equal to or less than 8.
Sign the informed consent form
Exclusion Criteria
The impossibility of using nasogastric tube feeding
Patients with severe trauma are candidates for craniotomy surgery
Pregnancy or breastfeeding
History of allergy to turmeric or curcumin product
Concomitant receipt of any drug or supplement with an antioxidant or anti-inflammatory effect or an approved immune system regulator
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method C-reactive protein (CRP). Timepoint: once at study entry and again after receiving the last dose of curcumin-piperine. Method of measurement: Laboratory tests.
- Secondary Outcome Measures
Name Time Method Glasgow Coma Scale (GCS). Timepoint: once at study entry and again after receiving the last dose of curcumin-piperine. Method of measurement: Clinical test.;Neutrophil-lymphocyte ratio (NLR). Timepoint: once at study entry and again after receiving the last dose of curcumin-piperine. Method of measurement: Laboratory test.;Sequential Organ Failure Assessment (SOFA) Score. Timepoint: once at study entry and again after receiving the last dose of curcumin-piperine. Method of measurement: Clinical test.