Determinants of Intra-individual Variation in Adaptability to Resistance Training of Different Volumes
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 42
- 试验地点
- 1
- 主要终点
- Thigh muscle cross-sectional area
研究概览
简要总结
The literature is not clear as to which training volume to employ during initial phases of resistance training programs to ensure optimal muscular adaptations. The purpose of this study is therefore to compare effects of strength training with low versus moderate volume on muscular function and hypertrophy in previously untrained, healthy individuals. Furthermore, the investigators will relate individual variation in responses to proxy markers of individual training state, such as baseline muscular function and muscle fiber type.
The study will include 25 women and 25 men and will consist of a 12-week resistance training protocol. Each study participant will act as their own control, performing both the low- (1-set) and the moderate-volume (3-sets) protocol, allocated to either the dominant or non-dominant leg, in a stratified and randomized fashion.
Primary outcome measures are thigh muscle cross section area and unilateral knee extension strength. Additionally, muscle fiber type composition will be evaluated as well as additional parameters of muscular function.
The primary hypothesis is that low-volume protocols will be beneficial for individuals with glycolytic muscle phenotypes, whereas the opposite will be true for individuals with more aerobic phenotypes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Non-smoking
- •Able to tolerate resistance exercise training
排除标准
- •Presence or history of cardiovascular, metabolic, endocrine or neuromuscular disease
- •Diagnosed mental health disorder
- •Intolerance to local anesthetic
- •No experience with exercise training
- •Performing regular resistance training (more than 1 session per week during last 12 months)
- •Impaired strength/ neuromuscular function due to previous injury
- •Recurrent pain in lower back, knee or shoulders
- •Taking prescribed medication that may affect outcome of training intervention
研究组 & 干预措施
Arm label 1-Set, 3-Set
12-week progressive strength training protocol of different volumes
干预措施: 12-week progressive strength training protocol (Behavioral)
结局指标
主要结局
Thigh muscle cross-sectional area
时间窗: Week 0 (baseline) and 12 (post training intervention)
Changes in muscle cross sectional area of each thigh from baseline to post intervention, assessed by MRI.
Unilateral knee-extension isometric strength
时间窗: Week 0 (baseline), 2, 5, 9 (during intervention) and 12 (after training intervention)
Time course changes in maximum knee extensor, isometric strength evaluated at 120° knee angle (180° fully extended).
次要结局
- Muscle strength(Week 0 (baseline), 2, 5, 9 (during intervention) and 12 (after training intervention))
- Blood hormonal profiles(Week 0 (baseline), 2 and 12 (post training intervention))
- Protein expression(Week 0 (baseline), 2 and 12 (post training intervention))
- Knee extensors and flexors force-velocity relationship(Week 0 (baseline), 2, 5, 9 (during intervention) and 12 (after training intervention))
- Muscle fiber cross-sectional area(Week 0 (baseline), 2 and 12 (post training intervention))
- Gene expression(Week 0 (baseline), 2 and 12 (post training intervention))