Diagnostic accuracy of MRI for neurodegenerative parkinsonism
Recruiting
- Conditions
- idiopathic parkinson's diseaseneurodegenerative parkinsonismParkinsons disease10028037
- Registration Number
- NL-OMON54005
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 180
Inclusion Criteria
- Age above 18
- DAT-SPECT scan between January 2019 and December 2021 for clinical uncertain
parkisonian
syndrom
Exclusion Criteria
- Indication for the DAT-SPECT other than CUPS
- Inability to provide informed consent
- Aboslute contra indication for MRI
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The diagnostic accuracy of the automated diagnostic software (mPDia, Heuron)<br /><br>using SMWI, compared with the final diagnosis of the neurologist.</p><br>
- Secondary Outcome Measures
Name Time Method <p>- Contrast ratio and size of the SN and LC on nmMRI<br /><br>- Iron content of SN and basal ganglia on SWI using QSM<br /><br>- T1 and T2 relaxation in different brain regions using MR STAT<br /><br>- Free-water present in the SN on DTI<br /><br>- Architecture of white matter tracts on DTI<br /><br>- Contrast ratio and size of the SN on nmSMWI<br /><br>- Hoehn & Yahr stage<br /><br>- MDS UPDRS that consists of the following four parts will be filmed:<br /><br>I. Non-motor experiences of daily living (6 items)<br /><br>II. Motor experiences of daily living (20 items)<br /><br>III. Motor examination (33 items)<br /><br>IV. Motor complications (6 items)<br /><br>- Red flags on the MDS criteria for the diagnosis of PD3<br /><br>- Montreal cognitive assessment (MoCA)<br /><br>- REM sleeping behavior disorder screening<br /><br>- Non-motor symptom assessment scale<br /><br>- Beck Depression inventory (BDI)<br /><br>- Environmental factors<br /><br>- Sebum swap</p><br>