Influence of PET/CT Radiomic Features on the Outcome of Lung Cancer Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 1,000
- 试验地点
- 2
- 主要终点
- Overall survival (OS) of lung cancer patients
研究概览
简要总结
Radiomics is an attractive field in objectively quantifying image features, and may overcome the subjectivity of visually interpreting computed tomography (CT), or positron emission tomography (PET). It is reported that the features related to treatment response, outcomes, tumor staging, tissue identification, and cancer genetics. Therefore, the investigators try to explore the key features for the outcome of lung cancer patients.
详细描述
Radiomic Features:
PET/CT images, including other kinds of CT serials, were transported into a personal computer. Using the open source software of 3D-Slicer, volumes of interest (VOIs) for primary tumor, or even lymph nodes, was semi-automatically or manually segmented. And then, radiomic features were extracted.
PET Parameters:
Using combined CT VOIs, corresponding PET standard uptake value (SUV, no unit) were measured. For a foci (either tumor, or lymph node), mean, sum and maximum SUV were documented, and were used for training and validating models alongside radiomic features.
Feature Selection:
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Pathologically diagnosed as lung caner.
- •Accepted PET/CT scans at the hospitals either affiliated to Shanxi Medical University or Anhui Medical University
- •Both PET and CT serials can be obtained
- •Can be followed for treatment modalities (including chemotherapy regimens, radiotherapy dose, and et al), survival time and status, and other related information.
排除标准
- •Simultaneously suffering from the cancers from other tissues and organs
- •Have a history of diabetes, chronic heart diseases, or chronic renal failure
结局指标
主要结局
Overall survival (OS) of lung cancer patients
时间窗: The patients were followed to December 31, 2019
The time from the scan date to death for any reason
次要结局
未报告次要终点
研究者
Hongwei Si
Chief physician
The First Affiliated Hospital of Shanxi Medical University