A Study to Learn About the Study Medicine Called PF-07220060 in Combination With Fulvestrant in People With HR-positive, HER2-negative Advanced or Metastatic Breast Cancer Who Progressed After a Prior Line of Treatment
- Conditions
- Advanced or Metastatic Breast Cancer
- Interventions
- Registration Number
- NCT06105632
- Lead Sponsor
- Pfizer
- Brief Summary
The purpose of this study is to learn about the safety and how effective the study medicine (PF-07220060) plus fulvestrant is compared to the study doctor's choice of treatment in people with advanced or metastatic breast cancer. Advanced cancer is the one that is unlikely to be cured or taken care of with treatment. Metastatic cancer is the one that has spread to other parts of the body.
This study is seeking female and male participants who:
* are 18 years of age or older;
* are hormone receptor (HR)-positive and human epidermal growth factor receptor 2 (HER2)-negative;
* have advanced or metastatic breast cancer after taking other treatments before this study;
* have not taken or need to take medications that are not allowed by the study protocol;
* do not have any medical or mental conditions that may increase the risk of study participation.
Half of the participants will take PF-07220060 two times daily by mouth along with fulvestrant. Fulvestrant will be given as a shot into the muscle. The other half will take the study doctor's choice of treatment which can either be:
* Fulvestrant alone taken as shot into the muscle.
* Everolimus along with exemestane taken once daily by mouth.
This study will compare the experiences of participants receiving the study medicine plus fulvestrant to those who are receiving the study doctor's choice of treatment. This will help decide if the study medicine is safe and effective.
Participants will receive study treatment and/or will be in the study until:
* imaging scans (such as an MRI and/or CT) show that their cancer is getting worse.
* the study doctor thinks the participant is no longer benefitting from the study medicine.
* has side effects that become too severe. A side effect is a reaction (expected or unexpected) to a medicine or treatment you take.
* the participant chooses to stop taking part.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 333
- Histological confirmation of breast cancer with evidence of locally advanced or metastatic disease, which is not amenable to surgical resection or radiation therapy with curative intent.
- Documented estrogen receptor (ER) and/or progesterone receptor (PR)- positive tumor
- Documented HER2-negative tumor
- Able to provide a sufficient amount of representative formalin fixed, paraffin embedded (FFPE) tumor tissue specimen.
- Must have received CDK4/6i plus NSAI defined per study protocol. There must be documented PD during or after CDK4/6i treatment.
- Measurable disease or non-measurable bone only disease as defined by RECIST version 1.1.
- Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) ≤2.
- Any medical or psychiatric condition that may increase the risk of study participation or make the participant inappropriate for the study.
- In visceral crisis at risk of immediately life-threatening complications in the short term.
- Known active uncontrolled or symptomatic central nervous system metastases, carcinomatous meningitis, or leptomeningeal disease.
- Prior treatment with any of the following:
- Everolimus or investigational anti-cancer agents in any setting
- Prior chemotherapy in the advanced setting
- Radiation within 2 weeks of randomization
- Current use or anticipated need for any prohibited food, supplements or concomitant medication(s) (ie, other anti-cancer therapies, other endocrine therapies, growth factors, chronic systemic corticosteroids, strong cytochrome P450 3A4/5 [CYP3A4/5] or uridine 5' diphosphate-glucuronosyltransferase 2B7 [UGT2B7] inhibitors and inducers, direct oral anticoagulants, proton pump inhibitors).
- Inadequate renal function, hepatic dysfunction, or hematologic abnormalities.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Arm A PF-07220060 CDK4 inhibitor PF-07220060 to be taken by mouth as a tablet in combination with fulvestrant (a solution for injection) Arm B Fulvestrant Investigator's choice of therapy of either: * Fulvestrant alone (a solution for injection), or * Everolimus in combination with exemestane, both a tablet to be taken by mouth. Arm A Fulvestrant PF-07220060 to be taken by mouth as a tablet in combination with fulvestrant (a solution for injection) Arm B Everolimus Investigator's choice of therapy of either: * Fulvestrant alone (a solution for injection), or * Everolimus in combination with exemestane, both a tablet to be taken by mouth. Arm B Exemestane Investigator's choice of therapy of either: * Fulvestrant alone (a solution for injection), or * Everolimus in combination with exemestane, both a tablet to be taken by mouth.
- Primary Outcome Measures
Name Time Method Progression-Free Survival (PFS) progression, as determined by investigator per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1 From Initiation up to 2 years
- Secondary Outcome Measures
Name Time Method Overall Survival (OS) Time from the date of randomization to the date of death due to any cause up to approximately 3 years OR by investigator per RECIST v1.1 Time From randomization date (every 8 weeks during the first 48 weeks and then every 12 weeks) to the date of progression OR death whichever occurs first (up to approximately 2 years) Duration of Response (DOR) as defined by investigator per RECIST v1.1 From the date of the first objective response (every 8 weeks during the first 48 weeks and then every 12 week) up to approximately 2 years. Number of Participants With Clinical Benefit Response (CBR) by investigator per RECIST v1.1 From randomization date (every 8 weeks during the first 48 weeks and then every 12 weeks) up to approximately 2 years Number or Patients with Adverse Events (AEs) by Type From screening until 28 days after the last dose, to approximately 3 years Number or Patients with AEs by Incidence From screening until 28 days after the last dose, to approximately 3 years Number or Patients with AEs by Seriousness From screening until 28 days after the last dose, to approximately 3 years Number or Patients with AEs by relationship to study interventions From screening until 28 days after the last dose, to approximately 3 years Number of Participants With Abnormal Electrocardiogram (ECG) From baseline to approximately 2 years Number of Participants With Laboratory Test Abnormalities From screening until 28 days after the last dose to approximately 2 years EQ-5D-5L Screening Days 1, 15 of Cycle 1 and 2, Day 1 of Cycles 3-6, then Day 1 of every other subsequent Cycle starting with Cycle 8 (eg, Cycles 8, 10, 12, etc) and EoT. Each Cycle is 28 days. EORTC QLQ Screening Days 1, 15 of Cycle 1 and 2, Day 1 of Cycles 3-6, then Day 1 of every other subsequent Cycle starting with Cycle 8 (eg, Cycles 8, 10, 12, etc) and EoT. Each Cycle is 28 days. EORTC QLQ Breast Cancer Module 23 (BR23) Screening Days 1, 15 of Cycle 1 and 2, Day 1 of Cycles 3-6, then Day 1 of every other subsequent Cycle starting with Cycle 8 (eg, Cycles 8, 10, 12, etc) and EoT. Each Cycle is 28 days. Ctrough of PF-07220060 Cycle 1 (Day 15), Cycle 2 (Day 1), and Cycle 3 (Day 1). Each Cycle is 28 days
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
Trial Locations
- Locations (221)
Fundación CORI para la Investigación y Prevención del Cáncer
🇦🇷La Rioja, Argentina
COE (Centro Oncológico de Excelencia)
🇦🇷San Juan, Argentina
Sanatorio Norte
🇦🇷Santiago del Estero, Argentina
Macquarie University
🇦🇺North Ryde, New South Wales, Australia
Beijing Cancer hospital
🇨🇳Beijing, Beijing, China
Chongqing University Cancer Hospital
🇨🇳Chongqing, Chongqing, China
The First People's Hospital of Foshan
🇨🇳Foshan, Guangdong, China
Kims Kingsway Hospital
🇮🇳Nagpur, Maharashtra, India
Apex Wellness Hospital
🇮🇳Nashik, Maharashtra, India
Sahyadri Super Speciality Hospital
🇮🇳Pune, Maharashtra, India
Bhakti Vedanta Hospital and Research Institute
🇮🇳Thane, Maharashtra, India
Highlands Oncology Group
🇺🇸Springdale, Arkansas, United States
UCSF - John Muir Health Cancer Center Berkeley
🇺🇸Berkeley, California, United States
Washington Hospital Healthcare System
🇺🇸Fremont, California, United States
Hoag Health Center Irvine
🇺🇸Irvine, California, United States
Hoag Hospital Irvine
🇺🇸Irvine, California, United States
Eisenhower George and Julia Argyros Health Center
🇺🇸La Quinta, California, United States
Keck Hospital of USC
🇺🇸Los Angeles, California, United States
Los Angeles General Medical Center
🇺🇸Los Angeles, California, United States
USC/Norris Comprehensive Cancer Center
🇺🇸Los Angeles, California, United States
Hoag Memorial Hospital Presbyterian
🇺🇸Newport Beach, California, United States
Eisenhower Health Center at South Palm Canyon
🇺🇸Palm Springs, California, United States
Keck Medical Center of USC Pasadena
🇺🇸Pasadena, California, United States
Eisenhower Medical Center
🇺🇸Rancho Mirage, California, United States
Zuckerberg San Francisco General Hospital and Trauma Center
🇺🇸San Francisco, California, United States
UCSF Medical Center at Mission Bay
🇺🇸San Francisco, California, United States
UCSF Cancer Center San Mateo
🇺🇸San Mateo, California, United States
Chronic Disease Clinical Research Center (CDCRC)
🇺🇸Torrance, California, United States
Clinical and Translational Research Center
🇺🇸Torrance, California, United States
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
🇺🇸Torrance, California, United States
Diagnostic and Wellness Center
🇺🇸Torrance, California, United States
Saint Vincent's Medical Center (SVMC)
🇺🇸Bridgeport, Connecticut, United States
Danbury Hospital
🇺🇸Danbury, Connecticut, United States
Hartford Hospital (HH)
🇺🇸Hartford, Connecticut, United States
MidState Medical Center (MMC)
🇺🇸Meriden, Connecticut, United States
Hartford Healthcare
🇺🇸New Britain, Connecticut, United States
Norwalk Hospital
🇺🇸Norwalk, Connecticut, United States
Hartford HealthCare Cancer Institute at The Hospital of Central Connecticut, Medical Arts Center
🇺🇸Plainville, Connecticut, United States
Georgetown University Medical Center
🇺🇸Washington, District of Columbia, United States
MedStar Washington Hospital Center
🇺🇸Washington, District of Columbia, United States
Summit Cancer Care, PC
🇺🇸Savannah, Georgia, United States
Advocate Good Shepherd Hospital
🇺🇸Barrington, Illinois, United States
Northwestern Memorial Hospital
🇺🇸Chicago, Illinois, United States
NorthShore University HealthSystem
🇺🇸Highland Park, Illinois, United States
Advocate Illinois Masonic Medical Center
🇺🇸Chicago, Illinois, United States
Advocate Good Samaritan Hospital
🇺🇸Downers Grove, Illinois, United States
Ascension Illinois - Evanston Infusion Center
🇺🇸Evanston, Illinois, United States
AMG Libertyville
🇺🇸Libertyville, Illinois, United States
Advocate Christ Medical Center
🇺🇸Oak Lawn, Illinois, United States
Advocate Lutheran General Hospital
🇺🇸Park Ridge, Illinois, United States
Ascension Illinois-Skokie Infusion Center
🇺🇸Skokie, Illinois, United States
Orchard Healthcare Research Inc.
🇺🇸Skokie, Illinois, United States
University of Iowa Health Care Cancer Services Quad Cities
🇺🇸Bettendorf, Iowa, United States
University of Iowa Hospitals & Clinics
🇺🇸Iowa City, Iowa, United States
Velocity Clinical Research
🇺🇸Annapolis, Maryland, United States
Brigham and Women's Hospital
🇺🇸Boston, Massachusetts, United States
Dana-Farber Cancer Institute
🇺🇸Boston, Massachusetts, United States
Dana-Farber Cancer Institute - Chestnut Hill
🇺🇸Newton, Massachusetts, United States
The University of Mississippi Medical Center
🇺🇸Jackson, Mississippi, United States
Intermountain Health St. Vincent Regional Hospital
🇺🇸Billings, Montana, United States
St. Vincent Frontier Cancer Center
🇺🇸Billings, Montana, United States
Cancer Care Specialists
🇺🇸Reno, Nevada, United States
Hackensack University Medical Center
🇺🇸Hackensack, New Jersey, United States
John Theurer Cancer Center at Hackensack University Medical Center
🇺🇸Hackensack, New Jersey, United States
Vassar Brothers Medical Center
🇺🇸Poughkeepsie, New York, United States
SUNY Upstate Medical University
🇺🇸Syracuse, New York, United States
Memorial Hermann Cancer Center
🇺🇸Houston, Texas, United States
Baylor Scott & White Medical Center - Round Rock
🇺🇸Round Rock, Texas, United States
Bon Secours Memorial Regional Medical Center
🇺🇸Mechanicsville, Virginia, United States
Bon Secours St. Francis Medical Center
🇺🇸Midlothian, Virginia, United States
Bon Secours at St. Mary's Hospital
🇺🇸Richmond, Virginia, United States
Swedish Medical Center
🇺🇸Seattle, Washington, United States
Aurora Health Center - Southern Lakes
🇺🇸Burlington, Wisconsin, United States
Aurora Medical Centers - Grafton
🇺🇸Grafton, Wisconsin, United States
Aurora BayCare Medical Center
🇺🇸Green Bay, Wisconsin, United States
Aurora Health Center - Kenosha
🇺🇸Kenosha, Wisconsin, United States
Aurora Health Center Milwaukee - Good Hope
🇺🇸Milwaukee, Wisconsin, United States
Aurora St Luke's Medical Center
🇺🇸Milwaukee, Wisconsin, United States
Aurora Medical Center - Summit
🇺🇸Summit, Wisconsin, United States
Aurora Cancer CAre
🇺🇸Wauwatosa, Wisconsin, United States
CIPREC
🇦🇷Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina
Centro de Investigaciones Metabólicas (CINME)
🇦🇷Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina
Fundación Cenit Para La Investigación En Neurociencias
🇦🇷Caba, Ciudad Autónoma DE Buenos Aires, Argentina
Organizacion Medica de Investigacion
🇦🇷Caba, Ciudad Autónoma DE Buenos Aires, Argentina
Hospital Británico de Buenos Aires
🇦🇷Caba, Ciudad Autónoma DE Buenos Aires, Argentina
Clinica Viedma S. A
🇦🇷Viedma, RÍO Negro, Argentina
Instituto de Oncología de Rosario
🇦🇷Rosario, Santa FE, Argentina
Sanatorio de La Mujer
🇦🇷Rosario, Santa FE, Argentina
Centro Para la Atención Integral del Paciente Oncologico (CAIPO)
🇦🇷San Miguel de Tucuman, Tucumán, Argentina
Exelsus - Oncología Clínica
🇦🇷San Miguel de Tucumán, Tucumán, Argentina
Fundación Respirar
🇦🇷Ciudad Autónoma Buenos Aires, Argentina
Centro Medico Austral
🇦🇷Ciudad Autónoma de Buenos Aires, Argentina
Clínica Universitaria Reina Fabiola
🇦🇷Córdoba, Argentina
Icon Cancer Centre Townsville
🇦🇺Rosslea, Queensland, Australia
Instituto D'Or de Pesquisa e Ensino (IDOR) - Filial Salvador
🇧🇷Salvador, Bahia, Brazil
Crio - Centro Regional Integrado de Oncologia
🇧🇷Fortaleza, Ceará, Brazil
Instituto D'Or de Pesquisa e Ensino (IDOR) - Filial Pernambuco
🇧🇷Recife, Pernambuco, Brazil
Liga Norte Riograndense Contra o Câncer
🇧🇷Natal, RIO Grande DO Norte, Brazil
ONCOSITE - Centro de Pesquisa Clinica em Oncologia
🇧🇷Ijui, RIO Grande DO SUL, Brazil
Irmandade da Santa Casa de Misericórdia de Porto Alegre
🇧🇷Porto Alegre, RIO Grande DO SUL, Brazil
Centro Gaucho Integrado De Oncologia, Hematologia, Ensino E Pesquisa
🇧🇷Porto Alegre, RIO Grande DO SUL, Brazil
Hospital São Lucas da PUCRS
🇧🇷Porto Alegre, RIO Grande DO SUL, Brazil
Centro de Pesquisa Clínica - Área Administrativa
🇧🇷Porto Alegre, RIO Grande DO SUL, Brazil
Hospital Mae de Deus
🇧🇷Porto Alegre, RIO Grande DO SUL, Brazil
Fundação Pio XII - Hospital de Câncer de Barretos
🇧🇷Barretos, SÃO Paulo, Brazil
Centro de Oncologia - CEON+ - Unidade São Caetano do Sul
🇧🇷São Caetano do Sul, SÃO Paulo, Brazil
Fundação Faculdade Regional de Medicina de São José do Rio Preto
🇧🇷São José do Rio Preto, SÃO Paulo, Brazil
Hospital de Base de São José do Rio Preto
🇧🇷São José do Rio Preto, SÃO Paulo, Brazil
Hospital Esperança Recife: Pronto Atendimento 24h
🇧🇷Pernambuco, Brazil
IBCC - Núcleo de Pesquisa e Ensino
🇧🇷São Paulo, Brazil
Dr. Everett Chalmers Regional Hospital
🇨🇦Fredericton, New Brunswick, Canada
Cape Breton Regional Hospital
🇨🇦Sydney, Nova Scotia, Canada
Royal Victoria Regional Health Centre
🇨🇦Barrie, Ontario, Canada
CIUSSS- saguenay-Lac-Saint-Jean
🇨🇦Chicoutimi, Quebec, Canada
Jewish General Hospital
🇨🇦Montreal, Quebec, Canada
CHU de Québec-Université Laval, Hôpital du Saint-Sacrement
🇨🇦Quebec City, Quebec, Canada
Anhui Provincial Cancer Hospital
🇨🇳Hefei, Anhui, China
Cancer Hospital Chinese Academy of Medical Science
🇨🇳Beijing, Beijing, China
Peking University People's Hospital
🇨🇳Beijing, Beijing, China
Guangdong Provincial People's Hospital
🇨🇳Guangzhou, Guangdong, China
Sun Yat-sen University Cancer Center
🇨🇳Guangzhou, Guangdong, China
Guangxi Medical University Affiliated Tumor Hospital
🇨🇳Nanning, Guangxi, China
Harbin Medical University Cancer Hospital
🇨🇳Harbin, Heilongjiang, China
The First Affiliated Hospital of Henan University of Science &Technology
🇨🇳Luoyang, Henan, China
Henan Cancer Hospital
🇨🇳Zhengzhou, Henan, China
Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology
🇨🇳Wuhan, Hubei, China
Hubei Cancer Hospital
🇨🇳Wuhan, Hubei, China
Hunan Cancer Hospital
🇨🇳Changsha, Hunan, China
Jiangsu Province Hospital
🇨🇳Nanjing, Jiangsu, China
Jilin Province Tumor Hospital
🇨🇳Changchun, Jilin, China
The First Hospital of Jilin University
🇨🇳Changchun, Jilin, China
The First Hospital of China Medical University
🇨🇳Shenyang, Liaoning, China
The First Affiliated Hospital of Xi'an Jiaotong University
🇨🇳Xi'an, Shaanxi, China
Fudan University Shanghai Cancer Center
🇨🇳Shanghai, Shanghai, China
West China Hospital of Sichuan University
🇨🇳Chengdu, Sichuan, China
Tianjin Medical University Cancer Institute & Hospital
🇨🇳Tianjing, Tianjin, China
Sir Run Run Shaw Hospital of Zhejiang University School of Medicine
🇨🇳Hangzhou, Zhejiang, China
Zhejiang Cancer Hospital
🇨🇳Hangzhou, Zhejiang, China
Taizhou Hospital of Zhejiang Province
🇨🇳Linhai, Zhejiang, China
The First Affiliated Hospital of Wenzhou Medical University
🇨🇳Wenzhou, Zhejiang, China
Rajiv Gandhi Cancer Institute And Research Centre
🇮🇳New Delhi, Delhi, India
Kiran Hospital - Multi Super Speciality Hospital and Research Center
🇮🇳Surat, Gujarat, India
Spandana Oncology Centre (SOC)
🇮🇳Bangalore, Karnataka, India
Tata Memorial Hospital
🇮🇳Mumbai, Maharashtra, India
GBH Memorial cancer Hospital and American International Institute of Medical sciences
🇮🇳Udaipur, Rajasthan, India
Apollo Multispeciality Hospitals limited
🇮🇳Kolkata, WEST Bengal, India
Soroka Medical Center
🇮🇱Be'er Sheva, Hadarom, Israel
Rabin Medical Center
🇮🇱Petah Tikva, Hamerkaz, Israel
Rambam Health Care Campus
🇮🇱Haifa, Hatsafon, Israel
Shaare Zedek Medical Center
🇮🇱Jerusalem, Yerushalayim, Israel
Aichi Cancer Center Hospital
🇯🇵Nagoya, Aichi, Japan
Nagoya University Hospital
🇯🇵Nagoya, Aichi, Japan
Chiba cancer center
🇯🇵Chiba-shi, Chiba, Japan
National Hospital Organization Shikoku Cancer Center
🇯🇵Matsuyama, Ehime, Japan
Gunma Prefectural Cancer Center
🇯🇵Otashi, Gunma, Japan
National Hospital Organization Hokkaido Cancer Center
🇯🇵Sapporo, Hokkaido, Japan
Tohoku University Hospital
🇯🇵Sendai, Miyagi, Japan
Osaka International Cancer Institute
🇯🇵Osaka-shi, Osaka, Japan
Osaka University Hospital
🇯🇵Suita, Osaka, Japan
Saitama Medical University International Medical Center
🇯🇵Hidaka, Saitama, Japan
St. Luke's International Hospital
🇯🇵Chuo-ku, Tokyo, Japan
The Cancer Institute Hospital of JFCR
🇯🇵Koto, Tokyo, Japan
Hiroshima City Hiroshima Citizens Hospital
🇯🇵Hiroshima, Japan
Okayama University Hospital
🇯🇵Okayama, Japan
National Hospital Organization Osaka National Hospital
🇯🇵Osaka, Japan
Inha University Hospital
🇰🇷Incheon, Incheon-gwangyeoksi [incheon], Korea, Republic of
National Cancer Center
🇰🇷Goyang-si, Kyǒnggi-do, Korea, Republic of
CHA Bundang Medical Center, CHA University
🇰🇷Seongnam-si, Kyǒnggi-do, Korea, Republic of
Seoul National University Bundang Hospital
🇰🇷Seongnam, Kyǒnggi-do, Korea, Republic of
Ajou University Hospital
🇰🇷Suwon-si, Kyǒnggi-do, Korea, Republic of
Pusan National University Hospital
🇰🇷Busan, Pusan-kwangyǒkshi, Korea, Republic of
Seoul National University Hospital
🇰🇷Seoul, Seoul-teukbyeolsi [seoul], Korea, Republic of
Kangbuk Samsung Hospital
🇰🇷Seoul, Seoul-teukbyeolsi [seoul], Korea, Republic of
Severance Hospital, Yonsei University Health System
🇰🇷Seoul, Seoul-teukbyeolsi [seoul], Korea, Republic of
Asan Medical Center
🇰🇷Seoul, Seoul-teukbyeolsi [seoul], Korea, Republic of
Gangnam Severance Hospital, Yonsei University Health System
🇰🇷Seoul, Seoul-teukbyeolsi [seoul], Korea, Republic of
Samsung Medical Center
🇰🇷Seoul, Seoul-teukbyeolsi [seoul], Korea, Republic of
Korea University Guro Hospital
🇰🇷Seoul, Seoul-teukbyeolsi [seoul], Korea, Republic of
Ewha Womans University Mokdong Hospital
🇰🇷Seoul, Seoul-teukbyeolsi [seoul], Korea, Republic of
Keimyung University Dongsan Hospital
🇰🇷Daegu, Taegu-kwangyǒkshi, Korea, Republic of
Cryptex Investigación Clínica S.A. de C.V.
🇲🇽Cuauhtémoc, Distrito Federal, Mexico
Mexico Centre for Clinical Research S.A de C.V
🇲🇽Mexico City, Distrito Federal, Mexico
COI Centro Oncologico Internacional S.A.P.I. de C.V.
🇲🇽Mexico City, Distrito Federal, Mexico
Boca Clinical Trials Mexico S.C.
🇲🇽Guadajalara, Jalisco, Mexico
Filios Alta Medicina S.A. de C.V.
🇲🇽Monterrey, Nuevo LEÓN, Mexico
Unidad de Investigación en Salud de Chihuahua, S.C.
🇲🇽Chihuahua, Mexico
Oaxaca Site Management Organization S.C.
🇲🇽Oaxaca, Mexico
Instituto Veracruzano en Investigación Clínica S.C.
🇲🇽Veracruz, Mexico
Tumor Zentrum Aarau
🇨🇭Aarau, Aargau, Switzerland
Kantonsspital Olten
🇨🇭Olten, Switzerland
China Medical University Hospital
🇨🇳Taichung, Taiwan
National Cheng Kung University Hospital
🇨🇳Tainan, Taiwan
National Taiwan University Hospital
🇨🇳Taipei, Taiwan
Mackay Memorial Hospital
🇨🇳Taipei, Taiwan
Taipei Veterans General Hospital
🇨🇳Taipei, Taiwan
Koo Foundation Sun Yat-Sen Cancer Center
🇨🇳Taipei, Taiwan
Chang Gung Medical Foundation-Linkou Branch
🇨🇳Taoyuan, Taiwan
TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi
🇹🇷Istanbul, İ̇stanbul, Turkey
Medipol Mega Universite Hastanesi
🇹🇷Stanbul, İ̇stanbul, Turkey
Acibadem Altunizade Hospital
🇹🇷Üsküdar / Stanbul, İ̇stanbul, Turkey
Ege Universitesi Hastanesi
🇹🇷Izmir, İ̇zmir, Turkey
Gulhane Egitim Arastirma Hastanesi
🇹🇷Ankara, Turkey
Dr. Abdurrahman Yurtaslan Ankara Onkoloji Egitim ve Arastırma Hastanesi
🇹🇷Ankara, Turkey
Hacettepe Universite Hastaneleri
🇹🇷Ankara, Turkey
Ultramar Medical Imaging Center
🇹🇷Ankara, Turkey
Memorial Ankara Hastanesi
🇹🇷Ankara, Turkey
Ankara Bilkent Şehir Hastanesi
🇹🇷Ankara, Turkey
Dicle Üniversitesi
🇹🇷Diyarbakir, Turkey
Marmara Universitesi Pendik Egitim Arastirma Hastanesi
🇹🇷Istanbul, Turkey
Erciyes Universitesi Tıp Fakultesi Hastaneleri
🇹🇷Kayseri, Turkey
Kocaeli Üniversitesi
🇹🇷Kocaeli, Turkey
Necmettin Erbakan Meram Medical Fac.
🇹🇷Konya, Turkey
Samsun Medical Park Hastanesi
🇹🇷Samsun, Turkey
The Princess Alexandra Hospital NHS Trust
🇬🇧Harlow, England, United Kingdom
The Royal Cornwall Hospital
🇬🇧Truro, England, United Kingdom
Imperial College Healthcare NHS Trust, Charing Cross Hospital
🇬🇧London, Hammersmith AND Fulham, United Kingdom
Sarah Cannon Research Institute UK
🇬🇧London, London, CITY OF, United Kingdom
University Hospital Coventry & Warwickshire
🇬🇧Coventry, Warwickshire, United Kingdom
The Royal Surrey County Hospital
🇬🇧Guildford, United Kingdom
The Christie NHS Foundation Trust
🇬🇧Manchester, United Kingdom
Great Western Hospital
🇬🇧Swindon, United Kingdom