AIRR Long-term PerspectivesCharacterization of neonatal chronic lung disease in former premature infants at the age of 2 and 5 years

Recruiting

• Conditions: P27.1; Bronchopulmonary dysplasia originating in the perinatal period

• Registration Number: DRKS00012429
• Lead Sponsor: WG VH-NG-829 (Helmholtz Association), German Center for Lung Research (Federal Ministry of Science)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2017-05-26
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 500

Inclusion Criteria

Preterm infants with or without later development of BPD and a gestational age (GA) = 32 weeks from the AIRR study (DRKS 00004600) with BPD (Arm 1) and without BPD (Arm 2).

Exclusion Criteria

Exclusion criteria were severe congenital malformations (e.g. hypoplastic left-heart syndrome, severe hypoplasia of the lungs or congenital diaphragmatic hernia),
chromosomal abnormalities (e.g. trisomy 13 or 18) , inborn errors of metabolism, and decision for palliative therapy directly after birth.

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Course of BPD at the age of 2 and 5 years, Investigation by means of MRI, ILFT and Proteomics

Secondary Outcome Measures

Name	Time	Method
eurological impairment at 2 and 5 years of age