Immunological Change and the Single Nucleotide Polymorphism (SNP) in Children With Irritable Bowel Syndrome (IBS)

• Conditions: Children; Irritable Bowel Syndrome

• Registration Number: NCT01131442
• Lead Sponsor: Chang Gung Memorial Hospital

Brief Summary

Currently, the pathophysiology of Irritable bowel syndrome( IBS) remains unclear . The purpose of this study is want to investigate the immunological changes in the children with IBS.

Detailed Description

Irritable bowel syndrome (IBS) is a highly prevalent functional gastrointestinal disorder.Many children suffered from this disease and had impact on their daily life. However, the underlying pathophysiologic mechanisms remain to be elucidate. Dysregulation of the gut immune system is considered an important pathophysiology. We want to investigate the immunological changes in the IBS children.

Study Timeline

• Study Start: 2008-11
• Status Verified: 2010-05
• Study First Submitted: 2010-05-25
• Study First Submitted QC: 2010-05-26
• Last Update Submitted: 2010-05-26
• Study First Posted: 2010-05-27
• Last Update Posted: 2010-05-27

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• (5-18y/o) with IBS,
• All patients had chronic or relapsing symptoms of IBS consistent with the ROME II criteria

Exclusion Criteria

• A history of psychologic disorders, probiotics, anti-inflammatory, analgesic, or immunosuppressive medication (nonsteroidal anti-inflammatory drugs, steroids) within the past 3 months were excluded

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

Chang Gung Memeorial Hospital; 🇨🇳 Keelung, Taiwan