Perception of Baby's Painful Cry in fMRI

Not Applicable

Completed

• Conditions: Magnetic Resonance Imaging; Neuronal Activity
• Interventions: Other: functional Magnetic Resonance Imaging (fMRI)

• Registration Number: NCT03190486
• Lead Sponsor: Centre Hospitalier Universitaire de Saint Etienne

Brief Summary

Crying is the primary signaling strategy available to the human newborn for eliciting parental care. Yet, the investigators only have superficial understanding of the information carried by cries, and how this information is perceived by parents. Using modern tools of sound processing and functional Magnetic Resonance Imaging (fMRI) experiment, this study aims to investigate cry-induced brain activation in adult depending on the cry's acoustic properties expressing various degrees of stress and distress levels. For that, Adults will be tested inside a fMRI magnet to determine their brain activations elicited by different babies cries according to whether the cry was evoked in a pain situation or not. The cerebral activity will be investigated in relation to acoustic features of cries (e.g. with pitch and/or roughness variations). To test if the gender or parentally of adult listeners influence their perceptions and brain responses, the task will be applied to 2 different groups (men and women not-parents). The hypothesis is that the brain of adult listeners will be able to discriminate adequately the intensity of the pain mediated by the cries. This process should involve brain areas such as the insular and the orbito frontal cortex that are known to participate in the integration of pain intensity and pain controls. The experiment should also determine which one of the acoustic features is able to transmit pain and to recruit brain areas involved in pain processes.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2017-06-15
• Study First Submitted QC: 2017-06-15
• Study First Posted: 2017-06-16
• Study Start: 2017-07-24
• Primary Completion: 2018-07-05
• Study Completion: 2018-07-05
• Status Verified: 2018-09
• Last Update Submitted: 2018-10-09
• Last Update Posted: 2018-10-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• Man or woman aged between 18 and 50
• Contact-less with children
• right-handed
• Giving their written informed consent
• Subject who agreed to communicate MRI results to their attending physician
• French Social Security affiliation

Exclusion Criteria

• any contraindications to pass an fMRI test
• Pregnant woman

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Men contact-less with children	functional Magnetic Resonance Imaging (fMRI)	functional Magnetic Resonance Imaging (fMRI).
Women contact-less with children	functional Magnetic Resonance Imaging (fMRI)	functional Magnetic Resonance Imaging (fMRI).
Father contact-less with children	functional Magnetic Resonance Imaging (fMRI)	functional Magnetic Resonance Imaging (fMRI).
Mother contact-less with children	functional Magnetic Resonance Imaging (fMRI)	functional Magnetic Resonance Imaging (fMRI).

Primary Outcome Measures

Name	Time	Method
BOLD (blood-oxygen-level dependent) -contrast imaging	at inclusion	Measure of blood-oxygen-level dependent with fMRI during listening to natural crying.

Secondary Outcome Measures

Name	Time	Method
BOLD (blood-oxygen-level dependent) -contrast imaging	at inclusion	Measure of blood-oxygen-level dependent with by fMRI during listening to artificial crying.
impact of gender and parenting on perception of baby's cry	at inclusion	Measure of blood-oxygen-level dependent with by fMRI during listening to artificial crying.

Trial Locations

Locations (1)

Service de Neurologie - CHU de Saint-Etienne; 🇫🇷 Saint-Etienne, France