The Association Mechanism Between the Microbiome and the Development of Community Pneumonia Was Studied Based on the Analysis of Pulmonary Microbiota - Host Interaction Network

Active, not recruiting

• Conditions: Community Pneumonia

• Registration Number: NCT06896019
• Lead Sponsor: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Brief Summary

1. The difference of lung flora between the healthy group and the CAP group was compared, and the core flora involved in the development of CAP was identified.

2. To predict the metabolites associated with CAP.

3. Identification of genes related to immune response in CAP.

4. Construct the pulmonary microbiota - host interaction network with metabolites as the link.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-06-01
• Primary Completion: 2024-06-01
• Status Verified: 2024-08
• Study First Submitted: 2025-03-20
• Study First Submitted QC: 2025-03-20
• Last Update Submitted: 2025-03-20
• Study First Posted: 2025-03-26
• Last Update Posted: 2025-03-26
• Study Completion: 2025-12-12

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 37

Inclusion Criteria

• According to the CAP clinical diagnostic criteria in the Guidelines for the Diagnosis and Treatment of Community-Acquired Pneumonia in Adults in China (2016 edition), cases eligible for community-acquired pneumonia were included and screened.

Exclusion Criteria

• Alveolar lavage fluid samples without electronic bronchoscopy were excluded for mNGS etiological examination of the case.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Community Pneumonia	1 weeks	mNGS

Trial Locations

Locations (1)

Sun Yat-sent Memorial Hospital; 🇨🇳 Guangzhou, Guangdong, China