The study on the effects on atherosclerotic diseases by periodontal treatment
- Conditions
- Periodontitis, Atherosclerosis
- Registration Number
- JPRN-UMIN000008071
- Lead Sponsor
- Okayama University
- Brief Summary
There was a positive correlation between LDL-C level and plasma IgG antibody titer to Porphyromonas gingivalis. According to the analysis under adjusted age, at a cut-off value of 5.04 for plasma IgG titer to Porphyromonas gingivalis, the IgG titer was significantly correlated with the level of low-density lipoprotein cholesterol (LDL-C). This study suggested that infection with periodontal bacteria (Porphyromonas gingivalis) is associated with the progression of atherosclerosis.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 150
Not provided
A)acute myocardial infarction (within 6 months) B)unstable angina C)severe heart diseases D)Cardiovascular surgery (within 6 months) E)cerebrovascular accidents (within 6 months) F)severe hepatitis or renal disease G)malignant tumors H)port control diabetes I)lipidosis with following conditions a) nephrotic syndrome b) hypothyroidism c)cushing Syndrome d)secondary hyperlipemia according to other diseases J)hyperlipemia according to medicine such as steroids K)perioperative patients L)patients with poor compliance
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Periodontitis: Periodontal probing depth, Blood IgG antibody titer to periodontal pathogens Atherosclerosis: Carotid artery Intima - media thickness, Serum lipid, Blood sugar
- Secondary Outcome Measures
Name Time Method Body Mass Index, Creatine phosphokinase, White blood cell, Urine occult blood, Pulse wave velocity, High - sensitivity C - reactive protein, Tumor necrosis factor - alpha, Adiponectin