Oral Oxytocin's Effects on Attention Control
- Registration Number
- NCT04493515
- Lead Sponsor
- University of Electronic Science and Technology of China
- Brief Summary
The main aim of the study is to investigate whether orally administered oxytocin (24IU) could modulate attention control using a social-emotional saccade/antisaccade eye-tracking paradigm.
- Detailed Description
Numerous studies have reported the effect of intranasally administered oxytocin on attentional processing including stimulus-driven bottom-up processing and top-down goal-directed inhibitory control. However, it is unclear whether the functional effects are mediated by the peptide directly entering the brain or indirectly via raising peripheral concentrations. One possible method of producing a similar pattern of increased peripheral oxytocin concentrations but without the possibility of direct entry into the brain would be to administer the peptide lingually. In the present double-blind, between-subject, placebo-controlled study, 80 healthy male subjects will be recruited and receive either oxytocin (24IU) or placebo control administered orally (lingual). 45 minutes after treatment subjects are required to complete a social-emotional saccade/antisaccade eye-tracking paradigm. This paradigm uses social (happy, sad, angry, fear, and neutral faces) as well as non-social (oval shapes) stimuli to explore social- and emotion-specific effects of orally administered oxytocin.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Male
- Target Recruitment
- 80
- Male, healthy participants
- Non smokers
- Previous or current medical, psychiatric, neurological disorder
- Regular medication
- Use of any psychoactive substances in the 24 hours before experiment
- Contra-indications for oxytocin
- Contra-indications for eye-tracking data acquisition
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Oral Oxytocin Oral Oxytocin Oxytocin orally (24 IU) Oral Placebo Oral Placebo Placebo orally (24 IU, identical ingredients, except the active agent)
- Primary Outcome Measures
Name Time Method Effect of oral oxytocin administration on saccade/antisaccade latencies towards social (facial) versus non-social (shape) stimuli 45 minutes - 100 minutes after treatment Comparison between social-specific saccade/antisaccade latencies (in milliseconds) between the oxytocin and placebo treatment conditions
Effect of oral oxytocin administration on error rates of saccade/antisaccade for social (facial) versus non-social (shape) stimuli 45 minutes - 100 minutes after treatment Comparison between social-specific error rates of saccade/antisaccade between the oxytocin and placebo treatment conditions.
- Secondary Outcome Measures
Name Time Method Emotion-specific effects of oral oxytocin administration on saccade/antisaccade latencies towards the separate facial emotions 45 minutes - 100 minutes after treatment Comparison between emotion-specific saccade/antisaccade latencies (in milliseconds) between the oxytocin and placebo treatment conditions
Emotion-specific effects of oral oxytocin administration on saccade/antisaccade error rates for the separate facial emotions 45 minutes - 100 minutes after treatment Comparison between emotion-specific saccade/antisaccade error rates between the oxytocin and placebo treatment conditions
Trial Locations
- Locations (1)
University of Electronic Science and Technology of China(UESTC)
🇨🇳Chengdu, Sichuan, China