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临床试验/NCT07070453
NCT07070453招募中不适用

Effect of Photodynamic Therapy as an Adjunct to Non-Surgical Treatment of Periodontitis

Egas Moniz - Cooperativa de Ensino Superior, CRL2 个研究点 分布在 1 个国家目标入组 20 人开始时间: 2025年4月8日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
招募中
发起方
入组人数
20
试验地点
2
主要终点
Microbiology outcome

研究概览

简要总结

Photodynamic therapy (PDT) is an innovative technique that utilizes light-activated agents, known as photosensitizers, to produce reactive oxygen species capable of targeting and eliminating pathogens. This therapeutic approach has been explored in a variety of medical fields due to its versatility and minimal invasiveness. In the context of periodontal diseases, PDT has emerged as a promising adjunctive treatment in the non-surgical management of periodontitis. Periodontitis, a chronic inflammatory disease caused by the accumulation of pathogenic bacteria in the subgingival environment, is often treated with mechanical debridement, including scaling and root planing (SRP). However, these conventional methods may not always achieve complete bacterial eradication. PDT, when used in conjunction with SRP, has the potential to significantly enhance bacterial elimination. The use of photosensitizers, activated by specific wavelengths of light, leads to the generation of singlet oxygen, which can effectively kill a broad spectrum of periodontal pathogens, including those resistant to antibiotics. As an adjunctive therapy, PDT can improve the clinical outcomes of non-surgical periodontitis treatment by reducing bacterial load, promoting tissue healing, and potentially decreasing the need for more invasive procedures. The ability of PDT to target bacteria without harming surrounding tissues makes it an attractive option for patients who require a non-invasive treatment approach. In conclusion, photodynamic therapy is a valuable addition to periodontal treatment regimens, offering enhanced bacterial reduction and improved therapeutic outcomes in the management of periodontitis.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
Double (Participant, Investigator)

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者
否

入选标准

  • •Patients aged 18 years or older with periodontitis diagnosed according to EFP/APA 2018 criteria and with at least 10 teeth in the mouth.

排除标准

  • •Periodontal treatment in the previous six months; use of antibiotics, NSAIDs or immunosuppressants in the previous six months; acute oral infection; pregnant or breastfeeding women; teeth with grade III mobility; pockets with PD > 10 mm; use of antimicrobial mouthwash in the previous two months; patients with diabetes mellitus.

研究组 & 干预措施

Non-surgical periodontal treatment

Active Comparator

Conventional non-surgical treatment - scaling and root planing

干预措施: Non-surgical periodontal treatment (Procedure)

Antimicrobial photodynamic therapy

Experimental

Scaling and root planing + aPDT (antimicrobial photodynamic therapy)

干预措施: Scaling and root planing + aPDT (Procedure)

结局指标

主要结局

Microbiology outcome

时间窗: From enrollment to the end of treatment at 3 months.

Changes in the microbiome collected from periodontal pockets sequencing 16S ribosomal RNA gene

次要结局

  • Clinical outcome(From enrollment to the end of treatment at 3 months.)

研究者

发起方
Egas Moniz - Cooperativa de Ensino Superior, CRL
申办方类型
Other
责任方
Sponsor

研究点 (2)

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