Intermittent preventive treatment with sulfadoxine-pyrimethamine versus intermittent screening and treatment of malaria in pregnancy
Not Applicable
- Conditions
- Pregnancy and ChildbirthMalaria
- Registration Number
- PACTR201202000272122
- Lead Sponsor
- ondon School of Hygiene and Tropical Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 5000
Inclusion Criteria
1.Presence of a first or second pregnancy.
2.Gestation between 16 to 30 weeks inclusive at first booking as determined by symphysio-fundal measurements.
3.Provision of written informed consent to join the trial.
4. Residence in the study area and intention to stay in the area for the duration of the pregnancy.
Exclusion Criteria
1.Absence of informed consent.
2.An intention to leave the study area before delivery.
3.A history of sensitivity to sulphonamides.
4.Clinical AIDS or known HIV positivity.
5.Presence of any systemic illness likely to interfere with interpretation of the results of the trial.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method ow birth weight;Maternal anaemia;Placental malaria
- Secondary Outcome Measures
Name Time Method Peripheral blood parasitaemia ;Maternal anaemia ;Episodes of clinical malaria;Serious adverse events in the mother;Adverse outcome of pregnancy ¿ abortions, still births and neonatal deaths.;Occurrence of congenital abnormalities;Feasibility and costs of each approach to the control of malaria in pregnancy;Cost per cases of maternal anaemia (severe and non-severe) and peripheral malaria averted. ;Acceptability of each approach by pregnant women and antenatal clinic staff