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临床试验/NCT04245878
NCT04245878已完成不适用

Interest of a Period of Fasting Before Extubation in Resuscitation Patients: a Prospective Observational Study

Centre Hospitalier Universitaire Dijon1 个研究点 分布在 1 个国家目标入组 101 人开始时间: 2019年12月17日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
已完成
入组人数
101
试验地点
1
主要终点
Surface of the antral area in mm²

研究概览

简要总结

Orotracheal extubation in resuscitation is a situation in which there is an elevated risk of inhalation. In resuscitation, enteral nutrition that is administered in a continuous flow is likely to accumulate in the stomach. Gastric motility in resuscitation patients may be impaired for many reasons:

  • Iatrogenic: Catecholamines, sedatives and opioids slow down the digestive system and decrease the tone of the lower esophageal sphincter
  • Shock, polytrauma, sepsis, pain or discomfort, or mechanical ventilation again create an alteration in gastric emptying.

Enteral nutrition is commonly discontinued to manage extubation, but it is not systematic. Discontinuation leads to a decrease in caloric intake.

Gastric ultrasound is a minimally invasive, reliable and promising means of monitoring that allows the stomach to be visualized directly. Studies on healthy subjects and in anaesthesia have made it possible to validate ultrasound in the context of the study of gastric content using both quantitative (including measurement of the antral area) and qualitative criteria. Measurement of the antral area was also studied in resuscitation. Antral area and gastric volume are closely related, with a correlation coefficient ranging from 0.6 to 0.91.

Identifying patients at risk of inhalation by ultrasound could allow individualized enteral nutrition management prior to extubation in the resuscitation unit, and thus optimize nutritional management.

The objective of the study is to identify factors associated with greated antral area in patients hospitalized in the intensive care unit. The hypothesis is that continued enteral nutrition before extubation is associated with increased gastric volume as measured by ultrasound.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Person or next of kin/designated representative has provided his or her non-opposition
  • Patient in medical or surgical intensive care, admitted for an urgent medical or surgical reason and for whom extubation have been planned by the practitioner in charge of the patient

排除标准

  • Person subject to legal protection (guardianship, trusteeship)
  • Person subject to a justice safeguard measure
  • Pregnant, parturient or breastfeeding woman
  • Anechoic patient or patient without an exploitable ultrasound window
  • History of gastric or esophageal surgery
  • Limitation of Care (LOC) order

研究组 & 干预措施

intensive care unit inpatient

Inpatient intubated resuscitation patient with a scheduled extubation

干预措施: gastric ultrasound (Other)

结局指标

主要结局

Surface of the antral area in mm²

时间窗: pre-extubation

Duration of enteral feeding interruption in hours

时间窗: pre-extubation

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

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