The Association of Endothelial Dysfunction and Cardiac Allograft Vasculopathy

National Taiwan University Hospital1 site in 1 country100 target enrollmentMarch 2003

ConditionsHeart Transplantation

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Heart Transplantation
Sponsor: National Taiwan University Hospital
Enrollment: 100
Locations: 1
Last Updated: 20 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

Progressive cardiac allograft vasculopathy (CAV) is a serious complication in long-term survivors after heart transplantation. Therefore, we hypothesize that CAV is a diffuse and progressive process, and endothelial function may play an important role in predicting clinical outcome after heart transplantation. Therefore, this single-blinded study is designed to evaluate endothelial function, microvascular flow response and morphology of coronary artery in cardiac allografts,

The simultaneous use of IVUS and Doppler wire instrumentation in different pharmacological stress;
Tl-201 SPECT (dipyridamole stress/rest); to evaluate the correlation of endothelial function, coronary morphology change and Tl-201 dipyridamole stress myocardial perfusion image.

Registry

clinicaltrials.gov

Start Date

March 2003

End Date

TBD

Last Updated

20 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

National Taiwan University Hospital

Eligibility Criteria

Inclusion Criteria

•Heart transplant receipients who undergoing the coronary angiographic follow-up as standard protocols.

Exclusion Criteria

•Acute illness conditions including infection, congestive heart failure (NYHA Fc III, IV), etc.
•Coronary angiographic finding: coronary stenosis\>30% (as grade III, IV by Klauss V et al, Am J Cardiol 1995; 76:463-6).
•Creatinine \>3.0 mg/dl