NCT01709487已完成1 期
Feasibility Study of Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for Patients With Stage III or Only Pleural Stage IV Ovarian Carcinoma in First Line Therapy
适应症
干预措施
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 19
- 试验地点
- 2
- 主要终点
- mortality rate
研究概览
简要总结
First line treatment for advanced ovarian carcinoma hyperthermic intraperitoneal chemotherapy (HIPEC) after optimal debulking.
详细描述
Addition of HIPEC to the standard first line treatment of ovarian carcinoma.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •stage III or only pleural stage IV ovarian carcinoma first line treatment
排除标准
- •incomplete surgery poor performance status bad general condition
研究组 & 干预措施
HIPEC surgery with chemotherapy
Experimental
- 3 courses of pre-operative chemotherapy: carboplatin AUC = 5 IV + paclitaxel 175 mg/m2 IV every 3 weeks
- Debulking surgery
- HIPEC with cisplatin 50 mg/m2 intraperitoneally at the end of surgery
- 3 courses of post-operative chemotherapy: carboplatin AUC = 5 IV + paclitaxel 175 mg/m2 IV every 3 weeks
干预措施: HIPEC (Procedure)
结局指标
主要结局
mortality rate
时间窗: 24 weeks
We will record the mortality rate of our interventions: 3 cycles of pre-operative chemotherapy, surgery and HIPEC, 3 cycles of post-operative chemotherapy.
次要结局
- Overall survival(3 years)
- progression free survival(3 years)
研究者
研究点 (2)
Loading locations...
相似试验
已完成
3 期
Adjuvant HIPEC in High Risk Colon CancerPeritoneal NeoplasmsColorectal NeoplasmsNCT02231086Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)204
招募中
2 期
Heated Intraperitoneal Chemotherapy in Primary Ovarian Cancer PatientsEpithelial Ovarian CancerFallopian Tube CancerOvarian CancerNCT03321188Andrea Jewell20
招募中
2 期
Hyperthermic Intraperitoneal Chemotherapy for the Treatment of Pancreatic Cancer and Peritoneal MetastasisMetastatic Malignant Neoplasm in the PeritoneumMetastatic Pancreatic CarcinomaMetastatic Pancreatic CarcinomaStage IV Pancreatic Cancer AJCC v8Metastatic Malignant Neoplasm in the PeritoneumNCT04858009Mayo Clinic40
Unknown
不适用
HIPEC in the Treatment of Stage IIc-IV Epithelial Ovarian Cancer After CRS (HIPECOC)Hyperthermic Intraperitoneal ChemotherapyOvarian CancerNCT04280185Second Affiliated Hospital, School of Medicine, Zhejiang University202
已完成
1 期
Adjuvant Hyperthermic Intraperitoneal Chemotherapy for Locally Advanced Gastric CancerLocally Advanced Malignant NeoplasmGastric CancerNCT02672865Loma Linda University4