A Study of the Correlation Between Portal Vein Thrombosis and Prognosis of Liver Transplantation
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 700
- 试验地点
- 1
- 主要终点
- Death
研究概览
简要总结
The goal of this observational study is to investigate the correlation between portal vein thrombosis (PVT) and the prognosis of liver transplantation. The main questions it aims to address are:
What is the prevalence of PVT? What are the risk factors associated with PVT? What is the prognostic impact of preoperative PVT on liver transplantation?
Participants are divided into two groups: the PVT group and the non-PVT group. The investigators will comparatively analyze the data of both groups, estimate the prevalence and risk factors of PVT, construct a predictive model for PVT that is applicable in clinical settings, and clarify the prognostic effects of PVT.
详细描述
The investigators aim to investigate the prevalence and risk factors of PVT, to develop a novel grading or rating system for PVT, and to explore the prognostic impact of preoperative PVT in liver transplantation.
The investigators will:
Recruit patients according to the inclusion/exclusion criteria and obtain signed informed consents. They will collect demographic and laboratory characteristics and classify patients into the PVT group and the non-PVT group based on preoperative ultrasound and/or computed tomography.
Collect patients' perioperative medical imaging, surgical procedures, pathology reports, postoperative treatments, follow-up data, and clinical endpoints.
Comparatively analyze the data of the PVT and non-PVT groups, estimate the prevalence and risk factors of PVT, construct a predictive model for PVT that is applicable in clinical settings, clarify the prognostic effects of PVT, and propose a grading/rating system for PVT.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Liver transplantation recipients
- •Aged 18 years or older.
排除标准
- •Retransplantation
- •Multi-organ transplantation
- •Portal vein tumor thrombus
结局指标
主要结局
Death
时间窗: 10 years
Rate of death from various causes after liver transplant
Postoperative portal vein thrombosis
时间窗: 10 years
Number of participants with portal vein thrombosis after liver transplant
Postoperative portal vein stenosis
时间窗: 10 years
Number of participants with portal vein stenosis after liver transplant
次要结局
- Postoperative complications(1 year)
研究者
Ru-zhou Cai
Principal Investigator
Beijing Friendship Hospital