The Role of Chair Exercise and Intergenerational Activities in Older Adults With Physico-Cognitive Decline Syndrome: An Investigation of Frailty and Serum Mature Brain-Dervied Neurotrophic Factor Level
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Frailty Syndrome Status
研究概览
简要总结
The goal of this clinical trial is to investigate the effects of chair exercise followed by intergenerational activity in frailty syndrome and changes in serum mBDN levels among older adults with Physio-Cognitive Decline Syndrome (PCDS), as a novel approach integrating physical and social intervention with biomolecular assessments
In older adults with PCDS
- Does A 16-week program of chair exercise followed by intergenerational activity improve handgrip strength (HGS), gait speed, MoCA-Ina scores, and health-related quality of life?
- Does a 16-week program of chair exercise followed by an intergenerational activity increase serum mBDNF level?
- Are serum mBDNF levels associated with MoCA-Ina scores, gait speed, and handgrip strength?
Intervention Group
Participants will undergo a 12-week structured chair exercise program, conducted with a trained exercise instructor and supervised by a physician for vital sign monitoring during each session. The frequency of sessions will increase progressively:
- Weeks 1-2: once weekly
- Weeks 3-6: twice weekly
- Week 7-12: three times weekly
Additional activities include (intervention and control group):
- Weeks 1 and 11: teleconference session on nutrition and physical exercise supported by electronic flyers (e-flyers).
- Weeks 3, 5, 7, 11, and 13: distribution of e-flyers on elderly nutrition and the muscle-brain axis.
Additional Activity (intervention group)
- Weeks 13-16: intergenerational activities at an orphanage with children aged >5 years
Assessments (intervention and control group):
- Week 1: serum mBDNF and HbA1c measurement
- Week 12 and 16: physical assessments (body weight, height, handgrip strength, gait speed, MoCA-Ina, and IADL) and serum mBDNF measurement.
Control Group:
The participant will receive general health education on performing physical exercise 1-3 times per week throughout week 1-16
详细描述
Population aging in Indonesia has led to a growing proportion of older adults experiencing functional and cognitive decline. Physio-cognitive decline syndrome (PCDS), defined as the coexistence of reduced physical performance (such as slow gait speed or weak handgrip strength) and mild cognitive impairment without disability or dementia, is considered an early and reversible stage that increases the risk of frailty, disability, and poor quality of life.
Chair exercise provides a safe and feasible intervention for older adults, with proven benefits in muscle strength, balance, and neurocognitive function, partly mediated through increased levels of brain-derived neurotrophic factor (BDNF). In parallel, an intergenerational activity involving direct interaction between older and younger individuals has shown promise in improving psychosocial well-being and cognitive outcomes.
This study integrates chair exercise with intergenerational activities to target the multidimensional nature of PCDS. Outcomes will focus on frailty status and changes in serum mature brain-derived neurotrophic factor (mBDNF) to establish a multimodal, culturally adapted strategy to support healthy aging in Indonesian older adults.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 60 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Aged 60-75 years
- •Meet diagnostic criteria for physio-cognitive decline syndrome (PCDS): gait speed <1.0 m/s and/or hand grip strength <28 kg (men) or <18 kg (women), and MoCA-Ina score 22-26
- •Instrumental Activities of Daily Living (IADL) score >5
- •Able to understand and follow instructions adequately
- •Willing to participate and provide written informed consent
排除标准
- 未提供
研究组 & 干预措施
Intervention Arm
Nutritional education + 12 weeks structured chair-based exercise (PEROSI protocol, progressive frequency from 1 to 3 sessions/week, 60 minutes/session, supervised online) followed sequentially by 4 weeks SHP-based intergenerational activities (8 sessions, 2x/week, 45 minutes/session, paired 1:1 elderly-child using AMIR educational materials at selected orphanages).
干预措施: Intervention 1 (Behavioral)
Control Arm
Nutritional education only (2 personalized dietitian tele-conferences at weeks 1 and 11; 5 educational e-flyers at weeks 3, 5, 7, 13, and 15)
结局指标
主要结局
Frailty Syndrome Status
时间窗: From enrollment to the end of treatment at 12 weeks
• Change in frailty syndrome status (assessed using Cardiovascular Health Study criteria: score 0 robust, 1-2 pre-frail, ≥3 frail) from baseline to week 16.
serum mature brain-derived neurotrophic factor (mBDNF)
时间窗: from baseline to week 16
Change in serum mature brain-derived neurotrophic factor (mBDNF) levels (measured by ELISA) from baseline to week 16.
次要结局
- Hand grip strength(from baseline to week 16)
- Gait Speed Test(baseline to week 16)
- Cognitive Function(from baseline to week 16)
- health-related quality of life (SF-12 questionnaire)(from baseline to week 16)
- serum mBDNF levels(baseline to week 16)
研究者
Agnes Rensa
Princial Investigator
Atma Jaya Catholic University of Indonesia