Brief Intervention for OCD Fears
试验速览
- 阶段
- 4 期
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- Yale Brown Obsessive-Compulsive Scale
研究概览
简要总结
The study will test the efficacy of propranolol or placebo, administered after reactivation of a previously acquired obsessive-compulsive disorder (OCD) fear, in reducing fear and avoidance in OCD.
详细描述
Twenty subjects with OCD will be enrolled in the study. Participants will complete baseline assessments of fear and avoidance. Participants will be randomly assigned to a single dose of propranolol 40mg or placebo, administered immediately after a fear reactivation procedure. Primary outcome assessment will be OCD symptoms and avoidance behavior in a behavioral avoidance task 2 weeks after the intervention
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Principal Diagnosis of Obsessive-Compulsive Disorder
排除标准
- •History of other serious psychiatric disorder
- •Current Major Depressive Disorder
- •Women who are pregnant or nursing
- •Current use of psychiatric medication
- •Persons planning to start another treatment during the study period
- •Any significant medical condition that might increase the risk or participation or use of medications that might negatively interact with propranolol
研究组 & 干预措施
Propanolol
Propranolol 40 mg capsule, given once after fear reactivation procedure
干预措施: Propanolol (Drug)
Placebo capsule
Placebo capsule, given once after fear reactivation procedure
干预措施: Placebo (Drug)
结局指标
主要结局
Yale Brown Obsessive-Compulsive Scale
时间窗: 2 weeks
Total score on this Clinician-administered measure of OCD symptoms
次要结局
- Behavioral Avoidance Task(2 weeks)
研究者
Franklin Schneier
Research Scientist
New York State Psychiatric Institute