Group B Streptococcus Infection and PROM Incidince
Not yet recruiting
- Conditions
- Premature Rupture of Fetal MembranesGroup B Streptococcal Infection
- Interventions
- Drug: To provide ampicillin sulbactam to pregnant women with premature rupture of membrane
- Registration Number
- NCT06735703
- Lead Sponsor
- Assiut University
- Brief Summary
To investigate incidince of prom with GBS infection and role of prophylaxis against it
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- Female
- Target Recruitment
- 150
Inclusion Criteria
- Pregnant women with prom after 34 wks festation
Exclusion Criteria
- Bleeding disorder
- emergency conditions
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Pregnant women after 34 wks with PROM To provide ampicillin sulbactam to pregnant women with premature rupture of membrane -
- Primary Outcome Measures
Name Time Method Incidince of prom with GBS infection and prophylaxis against it Baseline
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms link GBS infection to PROM pathogenesis and how does ampicillin sulbactam modulate these pathways?
How does ampicillin sulbactam prophylaxis compare to standard-of-care antibiotics in reducing PROM incidence in GBS-colonized pregnancies?
Which biomarkers predict GBS-induced PROM risk and response to beta-lactam prophylaxis in high-risk pregnancies?
What are the safety profiles and management strategies for ampicillin sulbactam use in GBS-infected pregnant women with PROM?
What combination therapies or alternative antibiotics show promise for GBS prophylaxis in preventing PROM compared to ampicillin sulbactam?