eural Substrate for Emotional Memory Schemas in Individuals with Early Life Adversity
- Conditions
- early life adversityemotional memoryemotional schemas due to childhood experiences10027946
- Registration Number
- NL-OMON51804
- Lead Sponsor
- Radboud Universiteit Nijmegen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 115
Normal or corrected-to-normal vision
Normal uncorrected or corrected-to-normal hearing
Willingness and ability to understand nature and content of the study
Ability to participate and comply with study requirements
Fluent in Dutch (>= B1 level)
History of or current or previous neurological or psychiatric disorders (except
depression), or other relevant medical history, cognitive impairments
History of or current brain surgery or epilepsy
Pregnancy
MRI incompatibility (unremovable metal parts in upper body [plates, screws,
serre-fines, dental plates (pontics), metal splinters, piercings or medicinal
plasters), active implant [e.g. Pacemaker, neuro stimulator, insulin pump
and/or hearing aid], head operation, epilepsy, claustrophobia).
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main study parameter is neural mechanism underlying the relationship<br /><br>between early-life-adversity and emotional schema memory effect. Therefore, a<br /><br>within-subject design with an fMRI measurement is conducted to investigate<br /><br>emotional schema memory effect and its neural correlates. Here we define<br /><br>emotional schema memory effect as: when a negative schema is activated by music<br /><br>mood induction procedures, the participants will have enhanced memory<br /><br>performance for negative stimuli at the behavioural level. At the neural level,<br /><br>we will analyze the encoding related activity particularly subsequent memory<br /><br>effect (SME) and spatial pattern (representational similarity) in the medial<br /><br>prefrontal cortex (mPFC) and hippocampus. </p><br>
- Secondary Outcome Measures
Name Time Method <p>Secondary study parameters are the measurements for attention and emotion bias<br /><br>(skin conductance recodings, self reports and eye-tracking data), which will<br /><br>control the specificity of the bias. It might be possible that memory bias<br /><br>effects are caused by biases in attention and emotion, therefore it is<br /><br>important for future use of the results to properly control by these<br /><br>parameters. </p><br>