Effecct in recovery of inflamation and respiratory function in chronic obstructive pulmonary disease.
- Conditions
- acute ecxacerbation of chronic obstroctive lung disease.Chronic obstructive pulmonary disease with acute exacerbation, unspecified
- Registration Number
- IRCT2016031425726N4
- Lead Sponsor
- Research council of School of Pharmacy, Shahid Beheshti University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 70
Inclusion criteria include;
Vitamin D deficiency (serum 25(OH)D < 50 nmol/l) ?
Postbronchodilator FEV1/FVC < 0.70, FEV1< 80 % and
diagnosis acute exacerbation of COPD confirmed by a physician
Age=40 years ?
Written informed consent ?
Ability to comply with all study requirements
Exclusion criteria include
Severe vitamin D deficiency (serum 25(OH)D <15 nmol/l),?
Use of a supplement containing more than 400 IU vitamin D per day
Diagnosed asthma
Diagnosed osteoporosis
Self-reported history of hypercalcaemia or nephrolithiasis
Self-reported presence of sarcoidosis
Diagnosed chronic kidney disease stage 4 or higher (eGFR=29 ml/min/1.73 m2)?
liver insufficiency child pough class B or C
Interfering malignant diseases
Life expectation of less than 1 year on the basis of concurrent disease
Current participation in a clinical rehabilitation program
Pregnant or lactating women, or subjects who intend to become
pregnant within the study period
Potentially unreliable patients and those judged by the investigator
to be unsuitable for the study
Serious mental impairment i.e. preventing to understand the study
protocol or comply with the study aim.
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Interleukin 6 and interleukin 8 and hsCRP LEVEL. Timepoint: day of admision and day 5. Method of measurement: ELISA.
- Secondary Outcome Measures
Name Time Method Modified medical research council dyspnea scale. Timepoint: day of admision-day 5 and mounth 3 after inclusion to study. Method of measurement: questionaire.;St george respiratory questionnaire quality of life. Timepoint: day 1 and 90 after admission. Method of measurement: Patient-reported Outcomes & questionnaire fill out.