The effectiveness of Combined oral contraceptive pills(COC) in prevention of corpus luteal cyst after oocyte retrieval in in vitro fertilization(IVF) technique, A randomized control trial

Not Applicable

Recruiting

• Conditions: Female infertile patients; In vitro fertilization; Combined oral contraceptive pills; Corpus luteal cyst; Oocyte retrieval

• Registration Number: TCTR20190802001
• Lead Sponsor: Mahidol university

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2019-06-19
• Study Start: 2019-08-02
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Female
• Target Recruitment: 130

Inclusion Criteria

1. Female patients at Infertility Unit who have indications for in vitro fertilization.
2. IVF using embryo cryopreservation according to the opinion of the obstetrician or have indications such as
- Have more than 20 oocytes.
- Endometrium has an inappropriate condition for embryo transfer.
- Genetic diagnosis is needed before embryo transfer
3. Women aged 18-45 years.
4. Those who volunteered to participate in research projects.

Exclusion Criteria

1. Contraindications of combined oral contraceptive pills include:
a. Women with history of abnormalities in the circulatory system especially the abnormalities related to thrombosis, deep vein thrombosis, pulmonary embolism, coronary heart disease or at other parts of the body.
b. Women with history of stroke.
c. Symptoms that are suspected to be myocardial infarction or cerebrovascular disease.
d. Migraine with symptoms such as vision disorders, aphasia and motor weakness.
e. Diabetes with vascular complications.
f. Pancreatitis related to high blood cholesterol.
g. Jaundice or severe liver disease
h. Cancer that may be stimulated by sex hormones such as breast cancer or genital organ cancer.
i. Liver tumor both mild and severe types.
j. Undiagnosed abnormal vaginal bleeding
k. Allergic to ethinyl estradiol or desogestrel
l. Smoker over the age of 35.
2. Ovarian cysts occur before the IVF process.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Incidence of corpus luteal cyst 2 and 4 weeks after oocyte retrieval Transvaginal ultrasonography and measure size of corpus luteal cyst

Secondary Outcome Measures

Name	Time	Method
Duration from oocyte retrieval to endometrial preparation after date of endometrial preparation Date calculation