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临床试验/NCT02389140
NCT02389140已完成不适用

Blood Flow Within Active Myofascial Trigger Points Following Massage

University of Colorado, Denver1 个研究点 分布在 1 个国家目标入组 28 人开始时间: 2015年3月1日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
已完成
入组人数
28
试验地点
1
主要终点
Change in Blood Flow as measured by microdialysis

研究概览

简要总结

The physiological response at the myofascial trigger point (MTrP) to massage is not known, yet would provide important objective evidence for a treatment effect and clarify the resolution process of a MTrP.

详细描述

The physiological response at the myofascial trigger point (MTrP) to massage is not known, yet would provide important objective evidence for a treatment effect and clarify the resolution process of a MTrP. The long-term goal is to understand how therapeutic intervention affects the physiology of the MTrP. The objective of the proposed research is to assess, in a placebo controlled trial, the effectiveness of trigger point release massage (also known as ischemic compression) on blood flow at an active MTrP. The central hypothesis is that the contraction nodule of an active MTrP is characterized by an ischemic state comprised of reduced blood flow and subsequent dysregulation in carbohydrate metabolism. The investigators hypothesize that trigger point release (TPR) can positively impact blood flow leading to a change in high energy carbohydrate tension. The present study has been formulated, in part, from a preliminary study conducted by the investigators, which supports reduced blood flow and physiological disruption at active MTrPs. The proposed research will provide a physiological basis for massage to corroborate subjective reports of reduced pain sensitivity, impart credibility to treatment techniques, and provide insight into a mechanism of action for healing the MTrP.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Other
盲法
Single (Participant)

入排标准

年龄范围
21 Years 至 49 Years(Adult)
性别
All
接受健康志愿者
否

入选标准

  • •Chronic or episodic tension-type headache
  • •active MTrP in upper trapezius
  • •age 21-49
  • •BMI between 18.5-24.9
  • •either gender
  • •any race or ethnicity

排除标准

  • •No or latent MTrP in the upper trapezius
  • •migraine 4+/month
  • •cluster headache
  • •fibromyalgia
  • •neurological disease (e.g. Alzheimer's disease, Parkinson's disease, muscular dystrophy, multiple sclerosis)
  • •cardiovascular disease (e.g. prior heart attack or stroke)
  • •pregnancy
  • •a bleeding disorder (Self-report of hemophilia, known lack/deficiency of clotting factors, or presently °taking anti-coagulants (e.g. warfarin, Coumadin))
  • •narcotic use
  • •currently receiving massage
  • •prior trigger point injection or needling therapies
  • •allergy to lidocaine-type anesthetics such as lidocaine and prilocaine

研究组 & 干预措施

Trigger point treatment

Experimental

Trigger point release

干预措施: Trigger point release (Other)

Ultrasound

Sham Comparator

Sham US at Trigger point

干预措施: Ultrasound (Other)

结局指标

主要结局

Change in Blood Flow as measured by microdialysis

时间窗: 1 hr pre intervention and 1 hr post intervention

次要结局

  • Change in Glucose as measured by microdialysis(1 hr pre intervention and 1 hr post intervention)
  • Change in Lactate as measured by microdialysis(1 hr pre intervention and 1 hr post intervention)
  • Change in Pyruvate as measured by microdialysis(1 hr pre intervention and 1 hr post intervention)

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

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