Blood Flow Within Active Myofascial Trigger Points Following Massage

Not Applicable

Completed

• Conditions: Myofascial Pain; Tension-type Headache
• Interventions: Other: Trigger point release; Other: Ultrasound

• Registration Number: NCT02389140
• Lead Sponsor: University of Colorado, Denver

Brief Summary

The physiological response at the myofascial trigger point (MTrP) to massage is not known, yet would provide important objective evidence for a treatment effect and clarify the resolution process of a MTrP.

Detailed Description

The physiological response at the myofascial trigger point (MTrP) to massage is not known, yet would provide important objective evidence for a treatment effect and clarify the resolution process of a MTrP. The long-term goal is to understand how therapeutic intervention affects the physiology of the MTrP. The objective of the proposed research is to assess, in a placebo controlled trial, the effectiveness of trigger point release massage (also known as ischemic compression) on blood flow at an active MTrP. The central hypothesis is that the contraction nodule of an active MTrP is characterized by an ischemic state comprised of reduced blood flow and subsequent dysregulation in carbohydrate metabolism. The investigators hypothesize that trigger point release (TPR) can positively impact blood flow leading to a change in high energy carbohydrate tension. The present study has been formulated, in part, from a preliminary study conducted by the investigators, which supports reduced blood flow and physiological disruption at active MTrPs. The proposed research will provide a physiological basis for massage to corroborate subjective reports of reduced pain sensitivity, impart credibility to treatment techniques, and provide insight into a mechanism of action for healing the MTrP.

Study Timeline

• Study Start: 2015-03
• Study First Submitted: 2015-03-02
• Study First Submitted QC: 2015-03-09
• Study First Posted: 2015-03-17
• Primary Completion: 2016-12
• Study Completion: 2017-01
• Status Verified: 2017-08
• Last Update Submitted: 2017-08-30
• Last Update Posted: 2017-09-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 28

Inclusion Criteria

• Chronic or episodic tension-type headache
• active MTrP in upper trapezius
• age 21-49
• BMI between 18.5-24.9
• either gender
• any race or ethnicity

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Exclusion Criteria

• No or latent MTrP in the upper trapezius
• migraine 4+/month
• cluster headache
• fibromyalgia
• neurological disease (e.g. Alzheimer's disease, Parkinson's disease, muscular dystrophy, multiple sclerosis)
• cardiovascular disease (e.g. prior heart attack or stroke)
• diabetes
• pregnancy
• a bleeding disorder (Self-report of hemophilia, known lack/deficiency of clotting factors, or presently °taking anti-coagulants (e.g. warfarin, Coumadin))
• narcotic use
• currently receiving massage
• prior trigger point injection or needling therapies
• allergy to lidocaine-type anesthetics such as lidocaine and prilocaine

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Trigger point treatment	Trigger point release	Trigger point release
Ultrasound	Ultrasound	Sham US at Trigger point

Primary Outcome Measures

Name	Time	Method
Change in Blood Flow as measured by microdialysis	1 hr pre intervention and 1 hr post intervention

Secondary Outcome Measures

Name	Time	Method
Change in Glucose as measured by microdialysis	1 hr pre intervention and 1 hr post intervention
Change in Lactate as measured by microdialysis	1 hr pre intervention and 1 hr post intervention
Change in Pyruvate as measured by microdialysis	1 hr pre intervention and 1 hr post intervention

Trial Locations

Locations (1)

University of Colorado Hospital; 🇺🇸 Aurora, Colorado, United States