Non-dipping Hypertension and the Human Chronobiome
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- Blood pressure [mmHg]
研究概览
简要总结
Hypertension is a common condition with a concomitant burden of stroke, kidney disease and myocardial infarction. Its prevalence in developed societies is increasing as they age, and in less developed countries, as their populations assume aspects of the Western diet and lifestyle. Nocturnal non-dipping hypertension (NDHT) - the failure of blood pressure (BP) to dip at night - is estimated to complicate ~40% of hypertensives and is associated with poor outcomes. Randomized controlled trials have shown that a reduction of daytime systolic blood pressure by as little as 5mmHg on average (towards a target of 140mmHg) translates into a measurable clinical benefit. The peak nocturnal difference may be ~15-20mmHg systolic, illustrating the substantial potential for incremental benefit by adequate blood pressure control across the 24 hour cycle in this population. In this study, the investigators wish (i) to establish through repeated assessment, the stability of the non-dipping phenotype (Phase 1), and (ii) to deeply phenotype non-dippers by using parameters assessing day/night patterns, the chronobiome (Phase 2). To facilitate data collection over the course of the study, the investigators use wearable devices and mobile phone applications.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Phase 1: Inclusion Criteria (Stability of the non-dipping phenotype)
- •>18 years of age,
- •Upper arm with intact skin, i.e. without areas of breached or injured skin visible, for ABP measurements,
- •24h mean wake SBP >145mmHg at baseline from 24hr-ABPM readings within the past 12 months,
- •Decline of <10% between mean day time and night time systolic pressures quantified per 24hr-ABPM within the past 6 months,
- •Own a smartphone.
排除标准
- •(Stability of the non-dipping phenotype)
- •Known history of severe psychiatric or cognitive conditions, for example mania, schizophrenia, or mental retardation.
- •Shift work, defined as recurring work between 22:00-05:00,
- •History of clinically significant obstructive sleep apnea;
- •Urine creatinine > 1.5 mg/dl in men or >1.3 mg/del in women,
- •Significant liver disease (>3x upper limit of normal),
- •Diabetes mellitus,
- •Transmeridian travel across ≥2 time zones in the month prior to ABP sessions,
- •Planned transmeridian travel across more than ≥2 time zones during the planned study activities;
- •> 2 drinks of alcohol per day;
- •Use of illicit drugs which affect blood pressure;
- •Use of pacemaker or implantable Cardioverter Defibrillator, (ICD);
- •Bilateral mastectomy;
- •Hypotension, defined as 90/60 mmHg assessed during the screening visit from ≥ 3 in-office measurements initiated after 10 minutes in seated upright position with 5 minute intervals between measurements;
- •History of Raynaud's phenomenon;
- •Known allergy against natural latex rubber (contained in ABP bladder and tubing);
- •Nursing or pregnant females.
- •Phase 2: Inclusion Criteria (Deeply phenotyping non-dipping hypertensives)
- •Inclusion Cohort 1 (case): non-dipping hypertensives 'NDHT'
- •>18 years of age,
- •Upper arm with intact skin, i.e. without areas of breached or injured skin visible, for ABP measurements,
- •24h mean wake SBP >145mmHg from 24hr-ABPM readings confirmed per data base query within the past 12 months prior to enrollment into Phase 1 and across two subsequent 24hr-ABP sessions during Phase 1,
- •Decline of <10% between mean day time and night time systolic pressures from 24hr-ABPM readings confirmed per data base query within the past 12 months prior to enrollment into Phase 1 and across two subsequent 24hr-ABP sessions during Phase 1,
- •Own a smartphone.
- •Inclusion Cohort 2 (control): matched healthy normotensives 'NT'
- •>18 years of age,
- •Upper arm with intact skin, i.e. without areas of breached or injured skin visible, for ABP measurements,
- •Healthy (as assessed by health history, physical exam and screening lab work),
- •24h mean wake SBP <130mmHg quantified per 24hr-ABPM,
- •Own a smartphone. 4.3.3 Inclusion Cohort 3 (control): matched dipping hypertensives 'DHT'
- •1) >18 years of age, 2) Upper arm with intact skin, i.e. without areas of breached or injured skin visible, for ABP measurements,
- •24h mean wake SBP >145mmHg from 24hr-ABPM readings,
- •Decline of >10% between mean day time and night time systolic pressures from 24hr-ABPM readings,
- •Own a smartphone.
- •Phase 2 - Exclusion Criteria Cohorts 1-3
- •History of severe psychiatric illness or cognitive conditions, for example ( mania, schizophrenia, or mental retardation;
- •Shift work, defined as recurring work between 22:00-05:00;
- •Clinically significant obstructive sleep apnea as assessed per WatchPAT device;
- •Urine creatinine > 1.5 mg/dl in men or >1.3 mg/del in women;
- •Significant liver disease (>3x upper limit of normal);
- •Diabetes mellitus;
- •Past diagnosis of gastroesophageal reflux disease,
- •Transmeridian travel across ≥2 time zones in the two weeks before the 48hr deep phenotype sessions;
- •Frequent transmeridian flyer (≥2 flights per month) across more than ≥2 time zones during the 12 months of study activities;
- •Use of oral or intravenous antibiotics in the 6 months prior to enrollment;
- •Any contraindication listed below in the separate paragraph "Contraindications for the use of CorTemp® Disposable Temperature Sensors";
- •Subjects, who have received an experimental drug, used an experimental medical device within 30 days prior to screening, or who gave a blood donation of ≥ one pint within 8 weeks prior to screening;
- •> 2 drinks of alcohol per day;
- •Use of illicit drugs which affect blood pressure;
- •Nursing or pregnant (pregnancy will be repeatedly assessed at the beginning of each of the four inpatient visits, i.e. prior to the start of blood draws);
- 另有 9 项未显示
研究组 & 干预措施
Control NT
matched healthy normotensives 'NT' (24h mean wake SBP <120mmHg)
干预措施: Ambulatory blood pressure measurements (Other)
Control DHT
matched dipping hypertensives 'DHT' (24h mean wake SBP >145mmHg and a decline of >10% between mean day time and night time systolic pressures)
干预措施: Ambulatory blood pressure measurements (Other)
Case NDHT
Healthy non-dipping hypertensives 'NDHT' (24h mean wake SBP >145mmHg at baseline and a decline of <10% between mean day time and night time systolic pressures)
干预措施: Ambulatory blood pressure measurements (Other)
结局指标
主要结局
Blood pressure [mmHg]
时间窗: 24-48 hours
Ambulatory blood pressure measurements (ABPM)
次要结局
- Dipping status [dimensionless ratio](24-48 hours)