Comparison of the Results of Bronchoalveolar Lavage Culture and Endotracheal Aspirate Culture in Intubated Critically Ill COVID-19 Patients

Completed

• Conditions: Bronchoalveolar Lavage; COVID-19 Pneumonia; Critical Illness
• Interventions: Procedure: endotracheal aspirate culture; Procedure: Bronchoalveolar lavage

• Registration Number: NCT05403489
• Lead Sponsor: Basri Cakiroglu

Brief Summary

Introduction: Secondary pneumonia is frequently seen in COVID-19 cases followed up intubated, and high mortality rates can be observed. Isolation of the agent with bronchoalveolar lavage (BAL) culture or endotracheal aspirate (ETA) culture may increase the success of treatment. This study aimed to retrospectively analyze the results of BAL and ETA cultures in intubated COVID-19 cases.

Methods: We routinely apply BAL culture with bronchoscopy or ETA culture within the first 48 hours after intubating. We retrospectively screened cases who underwent BAL and ETA. They were divided into two groups: Group B and E. Evaluated parameters were compared in both groups.

Results: Demographic data and blood test results were similar in both groups. Intensive care unit (ICU) and intubation durations, and culture positivity were statistically significantly higher in Group B. Although not statistically significant, the mortality rate was higher in Group E. The most growth microorganisms were Candida species.

Conclusion: Mortality rates were consistent with the literature. Since the microorganism isolation rate is higher with BAL and antimicrobial treatment is applied more effectively; early deaths were prevented and stay periods were prolonged. In contrast, these durations were shorter in the ETA group due to higher mortality. In intubated COVID-19 cases, a more effective treatment process can be carried out by clearing the airway with fiberoptic bronchoscopy and by specifically planning the treatment according to the BAL culture. This may have a positive effect on prognosis and mortality.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-01-01
• Primary Completion: 2021-12-31
• Study Completion: 2022-05-31
• Status Verified: 2022-06
• Study First Submitted: 2022-06-02
• Study First Submitted QC: 2022-06-02
• Last Update Submitted: 2022-06-02
• Study First Posted: 2022-06-03
• Last Update Posted: 2022-06-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 67

Inclusion Criteria

• Intubated COVID-19 patients
• Above 18 years old patients

Exclusion Criteria

• Non COVID-19 patients
• Non intubated COVID-19 patients
• Below 18 years old patients

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Group E (endotracheal aspirate)	endotracheal aspirate culture	Patients who received ETA\*\* were named Group E. \*\* ETA: Endotracheal aspirate
Group B (bronchoalveolar lavage)	Bronchoalveolar lavage	Patients who underwent BAL\* were named Group B \* BAL: bronchoalveolar lavage

Primary Outcome Measures

Name	Time	Method
Mortality	1 years	Mortality rate was higher in Group E. But not statistically significant.
Culture positivity	1 years	Significantly higher microbiological culture growth rate was obtained in Group B
Length of stay in intensive care unit	1 years	Significantly higher duration of stay in intensive care unit was found in Group B
Duration of intubation	1 years	Significantly higher duration of stay intubated was observed in Group B

Secondary Outcome Measures

Name	Time	Method
Microorganism	1 years	The most growing microorganism in both groups was the Candida species.

Trial Locations

Locations (1)

Hisar Intercontinental Hospital; 🇹🇷 Istanbul, Turkey