NCT03072979Unknown不适用
Reduction in Tumour Perfusion for Spine Metastasis Treated With Stereotactic Body Radiotherapy (SBRT)
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 18
- 试验地点
- 1
- 主要终点
- Reduction in vasculature
研究概览
简要总结
Pre-clinical evidence suggests that radiotherapy reduces tumour-associated vasculature. The investigators will conduct a single-arm prospective study to quantify the reduction in tumour vasculature post-radiotherapy
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 21 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥21 years of age
- •Proven metastatic disease, excluding haematological and germ cell neoplasms
- •Life expectancy >3 months, Eastern Cooperative Oncology group (ECOG) 0-2
排除标准
- •The patient must not have an allergy to gadolinium contrast that will limit the ability to image the tumour by MRI safely even with the use of premedication
- •eGFR < 30 mL/min or if patient is suffering from acute renal insufficiency
- •Prior radiotherapy to the specified region
- •Recent surgery to affected spinal levels, or patients requiring immediate surgical intervention
- •Spinal instability score (SINS) >12
- •Symptomatic cord compression (Bilksy grade 2 or 3), or worsening neurological deficits
- •Body weight of more than 120kg
- •Pregnancy
结局指标
主要结局
Reduction in vasculature
时间窗: 3 month
Reduction in vasculature measured by changes on Dynamic Contrast enhanced MRI
次要结局
未报告次要终点
研究者
Radiation Oncology
Dr Balamurugan Vellayappan
National University Hospital, Singapore
研究点 (1)
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